马钱子若干组分治疗实验性关节炎的比较研究  

Comparison of Effects of Several Portions Derived from Semen Strychni on Experimental Arthritis

作　　者：徐丽君[1] 魏世超[1] 陆付耳[1] 黄刚[1] 黄光英[1] 叶望云[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院中西医结合研究所,武汉430030

出　　处：《同济医科大学学报》2001年第6期564-565,共2页Acta Universitatis Medicinae Tongji

摘　　要：将马钱子提取物分离成 4部分 ,即马钱子粉 (A)、非生物碱 (B)、非士的宁生物碱 (C)、士的宁 (D) ,观察各部分对大鼠棉球肉芽增生及角叉菜胶引起足跖肿胀的影响。实验表明 :A和 C均明显抑制棉球肉芽的增生 ,给药后第 5 h明显抑制足跖肿胀 (P<0 .0 5 ) ,B和 D则几乎无作用。提示 A具有抗实验性关节炎作用 ,且有效部位为 C。The four portions derived from Semen strychni included Semen powder (SP), strychnine (ST), alkahoid without strychnine (AK) and non alkaloid (NA). These portions were introduced to treat the experimental arthritis such as Carrageenan induced rats hind paw swelling and the subcutaneous granuloma induced by implanting cotton ball in the rats. The results showed that SP and AK ont only markedly reduced the weight of subcutaneous granuloma ( P< 0 01), but also evidently inhibited the paw swelling 5 h after administion ( P <0 05). ST and NA had hardly effects. It is suggested that SP with the effective portion of TA has the anti inflammatory effect on experimental arthritis.

关 键 词：马钱子 生物碱 士的宁 类风湿性关节炎 动物实验 中药 

分 类 号：R259.932.2[医药卫生—中西医结合] R282.710.5[医药卫生—中医内科学]