孕妇口服维生素K1改善新生儿维生素K营养状况  

Vitamin K Supplementation to Pregnant Women Improved Vitamin K Nutritional Status of their Newborns

作　　者：张会丰[1] 李根山[1] 刘兰芬 张玉华[1] 乔立敏[1] 莫桂初[1] Martin J.Shearer Julie Harvey 

机构地区：[1]河北医科大学第二医院儿科,石家庄050000 [2]山西省太原市南城区医院妇产科 [3]伦敦圣托马斯医院维生素K研究室

出　　处：《中国公共卫生》2001年第10期867-868,共2页Chinese Journal of Public Health

基　　金：河北省科研基金资助项目 (项目编号 :982 7630 2 0 )

摘　　要：目的　探索早期预防维生素K缺乏性出血的有效途径。方法　通过孕妇口服维生素K1,观察能否改善其新生儿的维生素K营养状况。结果　对照组新生儿骨钙蛋白未羧化率高于维生素K组 (6 6 6 6 %± 18 2 0 %和 13 41%± 11 96 % ,P <0 ,0 0 1)。对照组新生儿PIVKA -Ⅱ的阳性率为 2 6 45 % ,而维生素K组PIVKA -Ⅱ阳性率降至 0 % (P <0 0 0 1)。结论让孕妇在分娩后期服用维生素K1可使其新生儿的维生素K营养状况得以改善 ,孕妇口服维生素K1是早期预防维生素K缺乏性出血的新途径。Objective To discuss the effective ways to prevent vitamin K deficiency bleeding early.Methods By vitamin K supplementation of pregnant women, to observe whether the vitamin K status of their newborns can be improved.The pregnant women pregnant for 36-38 weeks were divided into two groups randomly: vitamin K group and control group. In the vitamin K group, the pregnant women orally take vitamin K1 tablets (5mg/day) till labor. Cord blood samples were assayed for total osteocalcin and undercarboxylated osteocalcin and PIVAK-II.Basing on total osteocalcin and undercarboxylated osteocalcin, the undercarboxylated osteocalcin/ total osteocalcin was calculated.Results Percentages of undercarboxylated osteocalcin in vitamin K group were lower than those of control one (13.41%±11.96% to 66.66%±18.20%, P <0.001).In the control group, the PIVKA-II rate was 26.45%, whereas, in vitamin K group, the one drop to zero ( P <0.001).Conclusion Vitamin K supplementation to the pregnant women can improve the vitamin K status of their newborns.It is an alternative method for prevention of vitamin K deficiency bleeding.

关 键 词：维生素K缺乏性出血 骨钙蛋白未羧化率 新生儿 孕妇 

分 类 号：R722.15[医药卫生—儿科]