当归补血汤促进造血功能的成分及其作用的研究  

Effect of Components of Dang-Gui-Bu-Xue Decoction on Hematopenia

作　　者：宁炼[1] 陈长勋[1] 金若敏[1] 吴耀平[1] 张海贵[1] 孙成立[1] 宋纯清[1] 胡之璧[1] 

机构地区：[1]上海中医药大学,上海200032

出　　处：《中国中药杂志》2002年第1期50-53,共4页China Journal of Chinese Materia Medica

基　　金："九五"国家攀登项目 ( 98PD0 9)

摘　　要：目的 :探讨当归补血汤不同的组分或成分对血虚模型小鼠造血功能的作用及其机理。方法 :采用整体实验法、MTT比色法、3 H TdR参入法、半固体造血细胞集落形成技术等 ,测定血虚小鼠外周血象、骨髓有核细胞数和造血干 /祖细胞集落水平。结果 :当归补血汤的多糖与非多糖组分均有补血作用 ,多糖组分作用较强 ,尤以当归多糖的作用更为显著。非多糖组分中以阿魏酸作用最强 ,黄芪异黄酮等也有一定的作用。以上各成分可在不同的作用环节上促进造血细胞的形成。结论 :当归补血汤通过多成分。Objective: To investigate the effects and the related mechanisms of the components of Dang-Gui-Bu-Xue decoction (DGBXD) on improving blood deficiency. Method: The effects of promoting hematopoietic function were observed with the blood difficient model mice, by giving components of DGBXD. RBC, WBC, reticulocytes and bone marrow nucleated cells (BMNC) were determined. The components of DGBXD on proliferation of BMNC and on clony forming unit (CFU) were also determined. Result: The components of DGBXD remarkably increased the quantity of RBC, WBC, and BMNC. Some of the components promoted the proliferation of BMNC and increased the quantity of CFU-Mix. Among them, polysaccharide of angelica was most potent. Conclusion: The studies show that the extracts and some components of DGBXD can promote the hemopoietic function system of the model mice, and they exert the effects in a comprehensive way.

关 键 词：当归补血汤 造血功能 成分 作用机理 

分 类 号：R285.5[医药卫生—中药学]