ACE基因多态性与原发性高血压左心室功能和结构的关系研究  

The relationship of the left ventricular function and hypertrophy with polymorphism of the angiotensin-converting enzyme gene in essential hypertension.

作　　者：林婴[1] 陶剑虹[1] 尹立雪[1] 杨明清[1] 黄文芳[1] 杜琼[1] 李春梅[1] 邓燕[1] 程力剑[1] 李刚[1] 

机构地区：[1]四川省人民医院,四川成都610072

出　　处：《四川医学》2002年第2期169-171,共3页Sichuan Medical Journal

摘　　要：目的　评价原发性高血压左心室不同功能状态和肥厚的ACE基因多态性频率分布 ,探讨ACE基因多态性对原发性高血压左心室功能和肥厚的影响。方法　采用超声技术评价左心室结构 (左心室室壁厚度 )和收缩功能指标 (射血分数 )。分别依据左心室室壁厚度 (正常与增厚 )、收缩功能 (正常、亢进和减低 )不同状况分组。PCR反应检测不同分组组内ACE基因多态性并计算其频率分布。结果　原发性高血压患者ACE基因型中DD型频率分布与左心室肥厚无关 ;Ⅱ型频率分布在左心室肥厚组高于非肥厚组 ,P =0 0 2 7。左心室收缩功能正常组与功能异常组之间 ,ACE各基因型频率分布无显著性差异 ;收缩功能异常组内收缩功能亢进与功能减低亚组间Ⅱ基因型频率分布具有显著性差异 ,P <0 .0 5。结论　①左心室收缩功能亢进与收缩功能减低时ACEⅡ基因型频率分布存在差异 ,表明ACE基因在收缩功能不同异常状态中可能存在不同效应 ;Objective This research will focus on the evaluation of the frequency distribution of polymorphism of ACE gene in different types of left ventricular function and left ventricular hypertrophy in essential hypertension.Methods Echocardiographic techniques were used for the measurement of end diastolic thickness of left ventricular wall and the ejection fraction of the left ventricle.According as the parameters of cardiac anatomic structure and function,the patients were separated into non hypertrophy group,hypertrophy group,normal systolic function group,hyper systolic function group and hypo systolic function group.PCR techniques were used for the detection of polymorphism of ACE gene.The frequency distribution of Ⅱ,ID and DD ACE genotypes was counted subsequently.Results No significant frequency distribution odds of DD between hypertrophy group and non hypertrophy group.The frequency distribution of Ⅱ in hypertrophy group was higher than non hypertrophy groups( P =0.027).There were no significant odds of frequency distribution of ACE genotypes between normal systolic function group and the abnormal systolic function group.The frequency distribution of Ⅱ in hyper systolic function group was higher than hypo systolic function groups( P <0.05).Conclusion The frequency distribution odds of Ⅱ between hyper systolic function group and hypo systolic function group demonstrated that a different effect of ACE polymorphism might exist in different systolic function status of the left ventricle.This primary results indicated that a higher frequency distribution of Ⅱ in hypertrophy group may be related to the old age and ACE inhibitor sensitivity of the patient for the ventricular structure modification.

关 键 词：血管紧张素转换酶基因多态性 左心室功能 左心室肥厚 原发性高血压 

分 类 号：R544.1[医药卫生—心血管疾病]