倍氯米松对变应性鼻炎鼻分泌物中粒性活细胞内钙离子浓度的影响  

The effects of BDP on calcium ion in the granular leukocytes in nasal secretions of the patients with allergic rhinitis

作　　者：沈志忠[1] 王豪[2] 王挥戈[1] 林珏龙 陈耀文 宋德辉[1] 

机构地区：[1]汕头大学医学院第一附属医院耳鼻咽喉科,广东汕头515041 [2]汕头大学医学院第二附属医院耳鼻咽喉科 [3]汕头大学医学院中心实验室

出　　处：《临床耳鼻咽喉科杂志》2002年第1期25-26,共2页Journal of Clinical Otorhinolaryngology

基　　金：广东省医学科学技术研究基金资助项目 (No .A19994 11)

摘　　要：目的 :探讨倍氯米松对变应性鼻炎鼻分泌物中粒性活细胞的作用机制。方法 :采用激光共聚焦显微镜扫描和荧光技术 ,观察变应性鼻炎鼻分泌物中嗜酸性粒细胞、中性粒细胞经倍氯米松处理后细胞内钙离子浓度([Ca2 + ]i)的变化。结果 :经倍氯米松处理后 ,嗜酸性粒细胞、中性粒细胞 [Ca2 + ]i 明显升高。结论 :倍氯米松能够使嗜酸性粒细胞和中性粒细胞 [Ca2 + ]i 升高 。Objective:To study the effects of beclomethasone dipropionate (BDP) on the inflammatory granular leukocytes in nasal secretions of the patients with allergic rhinitis.Method:The change of intercellular calcium ion of the eosinophils and neutrocytes in the nasal secretions were observed under the laser scanning confocal microscopy and technology of fluorescence.Result:The concentration of intercellular calcium ion either in eosinophils or in neutrocytes significantly rose after BDP treatment.Conclusion:BDP can rise the concentration of intercellular calcium ion in the granular leukocytes,which may be a factor of the anti inflammation functions of BDP.

关 键 词：激光扫描共聚焦显微镜 倍氯米松 应变性鼻炎 嗜酸性粒细胞 钙离子 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]