参白口服液对病毒性心肌炎心肌组织INOS表达的影响  

Effect on INOS of Heart Muscle in Viral Myocarditis by Shenbai Oral Liquor

作　　者：郭书文[1] 曹洪欣[2] 周令望[3] 

机构地区：[1]北京中医药大学东直门医院,北京100700 [2]黑龙江中医药大学 [3]哈尔滨医科大学

出　　处：《中国中医药信息杂志》2001年第11期38-39,共2页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金资助课题(№:30070940)

摘　　要：目的:研究NO与病毒性心肌炎(VMC)发生发展的关系及参白口服液的防治作用。方法:给BALB/C小鼠接种嗜鼠心肌柯萨奇B3病毒(CVB3m)诱发VMC,在接种后3、7、14、20、30d动态对照观察VMC的检出(光、电镜)及小鼠心肌组织INOS表达(免疫组化)情况。结果:CVB3m可引起VMC,受检心肌中INOS的阳性率表达为95.8%,中药组的表达量明显减少(P<0.05)。结论:NO的变化可能参与VMC的发生和发展,参白口服液有良好的防治作用。Objective:To study on relationship between NO and the development of viral myocarditis(VMC),and the prevention and treatment functions of Shenbai oral liquor. Methods:The viral myocarditis in BALB/C mouse was obtained by coxsackie virus B3m(CVB3m). The VMC and proteins INOS of mouse heart muscle in various stages(The days of 3,7,14,20,30)of virul infection were determined by optical and electron microscope and immunohistochemical methods comparatively. Results:CVB3m could cause VMC. The INOS positive rate of detected heart muscle in model group was 95.8%, and the Chinese medicine group's decreased obviously(P<0.05). Conclusion:NO plays important parts in the development of VMC, and Shenbai oral liquor has significant functions of prevention and treatment.

关 键 词：病毒性心肌炎 参白口服液 INOS 

分 类 号：R259.422.1[医药卫生—中西医结合]