急性心肌梗死与稳定型心绞痛患者血清肿瘤坏死因子-α及其受体水平的研究  

Detection of serum tumor necrosis factor-α and its receptor in patients with acute myocardial infarction and stable angina pectoris

作　　者：郑菱[1] 巩岩霞[1] 路秀文[1] 李桂苓[1] 张莲风[1] 王金良[1] 

机构地区：[1]天津公安医院,天津300050

出　　处：《中国中西医结合急救杂志》2001年第5期304-305,共2页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

基　　金：天津市公安局科研基金资助项目 (No.98YX 0 5 )

摘　　要：目的 :探讨肿瘤坏死因子 α(TNFα)及其受体在缺血性心血管疾病发病中的作用。方法 :采用双抗体夹心酶联免疫分析法分别检测了 6 7例冠心病患者 (急性心肌梗死 38例 ,稳定型心绞痛 2 9例 )和 19例健康人血清中的 TNFα及其可溶性受体 (s TNFR 、s TNFR )水平。结果 :冠心病患者血清中的 TNFα及其受体 s TNFR 、s TNFR 均明显高于对照组 ;两疾病组患者血清中的 TNFα水平间亦有显著性差异 ,但其 s TNFR 和 s TNFR 水平无显著性差异。结论 :TNFα及 s TNFR 、s TNFR 与缺血性心血管疾病的发生。Objective:To investigate the effects of tumor necrosis factorα(TNFα) and its receptor on pathogenesis of ischemic cardiovascular diseases(ICVD).Methods:Using the method of both antibody enzyme linked immunosorbent assay (BAELISA) the levels of serum TNFα and its soluble receptor (sTNFRⅠ?sTNFRⅡ) were detected in 67 cases with coronary heart disease (CHD),including 38 cases with acute myocardial infarction(AMI) and 29 cases with stable angina pectoris(SAP),and 19 healthy persons as control.Results:The levels of TNFα,sTNFRⅠ and sTNFRⅡ in patients with CHD were significantly higher than those in control group,meanwhile the differences of them between AMI and SAP were significant but there were not significant differences between sTNFRⅠ and sTNFRⅡ.Conclusions:There is a tight relation between the levels of serum TNFα,sTNFRⅠ,sTNFRⅡ and the occurrence and progression of ICVD.

关 键 词：肿瘤坏死因子-Α 肿瘤坏死因子-α受体 冠心病 急性心肌梗死 

分 类 号：R542.22[医药卫生—心血管疾病]