国产多沙唑嗪及特拉唑嗪对比治疗原发性高血压  

Clinical comparison of the efficacy of doxazosin and terazosin in treatment of essential hypertension

作　　者：孙兴昌[1] 樊朝美[1] 李一石[1] 明广华[1] 刘国仗[1] 陈君柱[2] 陆风祥[3] 

机构地区：[1]中国医学科学院中国协和医科大学心血管病研究所阜外心血管病医院临床药理研究室,北京100037 [2]浙江大学医学院附属第一医院,杭州310003 [3]江苏省人民医院,南京210029

出　　处：《中国新药杂志》2001年第9期692-695,共4页Chinese Journal of New Drugs

摘　　要：目的 :评价国产多沙唑嗪 (doxazosin)治疗原发性高血压病的疗效及安全性。方法 :2 2 7例坐位舒张压(SeDBP)为 12 .6 7～ 15 .33kPa的原发性高血压患者 ,随机分为 2组 ,分别服用多沙唑嗪 2mg ,qd ;或特拉唑嗪 2mg ,qd。药后 2周末SeDBP≥ 12 .6 7kPa者 ,二药剂量分别加倍 ,继续服用 2周 ,治疗共 4周。以安慰剂期末 (药前 )及治疗后 2 ,4周测诊室血压、心率并记录症状、体征及实验室检查指标 ,评价其疗效和安全性。结果 :治疗 4周后多沙唑嗪组有效率 6 7.0 % (75 /112 ) ,特拉唑嗪组 6 3 .4% (6 4/10 1) ,2组比较无显著性差异 (P >0 .0 5 )。 2组坐位收缩压(SeSBP) /SeDBP均下降 ,血压下降幅度无显著性差异 (P >0 .0 5 )。多沙唑嗪组 5 9例加量至 4mg ,特拉唑嗪组 5 2例加量至 4mg。二药其他常见的不良反应相似 ,为头晕、头痛、心悸及乏力 ,多可耐受 ,继续用药后逐渐消失。 2组实验室检查未见有临床意义的变化。结论 :多沙唑嗪 2～ 4mg·d-1可以有效治疗原发性高血压 。Objective:To evaluate the efficacy and safety of doxazosin in treatment of essential hypertension.Methods:227 patients with seated diastolic BP(SeDBP) of 12.67～15.33kPa were randomly divided to receive 2 mg once daily doxazosin or 2 mg terazosin once daily for 2 weeks.Patients with a SeDBP higher than 12.67kPa in the end of treatment were treated with double dose of doxazosin or terazosin for another 2 weeks.The patients baseline BP,heart rate,clinical safety,and specific symptoms at the end of the first and the second 2 weeks treatment and the efficacy and safety of doxazosin was evaluated by these parameters.Results:After 4 weeks treatment,there were no significant difference in effective rate of doxazosin(67.0%,75/112) and terazosin (63.4%,64/101),no significant difference in decrease range of SeSBP/SeDBP( P >0.05).The number of patients receiving a double dose were 59 for doxazosin and 52 for terazosin.The two drugs have similar adverse reaction such as dizziness,headache,palpitation and hypodynamia,and they were tolerable and disappeared in continuous treatment.Conclusion:Essential hypertension can be effectively treated with doxazosin in once daily dose of 2～4mg.

关 键 词：多沙唑嗪 特拉唑嗪 原发性高血压 

分 类 号：R972.4[医药卫生—药品] R544.1[医药卫生—药学]