不同年龄高血压患者大动脉扩张性的临床研究  

Clinical study of distensibility of large arteries in patients with essential hypertension of different age groups

作　　者：王宏宇[1] 龚兰生[2] 张维忠[2] 孙宁玲[1] 胡大一[1] 

机构地区：[1]北京大学人民医院心脏内科,北京100044 [2]上海第二医科大学附属瑞金医院上海市高血压研究所,上海200025

出　　处：《中华老年心脑血管病杂志》2001年第6期384-386,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的　探讨不同年龄段高血压患者大动脉弹性的改变及其影响因素。方法　应用脉搏波传导速度 (pulsewavevelocity ,PWV)自动测量系统测定颈动脉 股动脉PWV作为反映大动脉扩张性的参数。对 1392例高血压患者进行了PWV检测 ,其中男 95 4例 ,女 438例 ,年龄 14～ 85岁 ,平均 (5 2 .0 9± 12 .37)岁。结果　 1392例高血压患者的研究结果显示PWV随年龄增大 (不论男性还是女性 )而增加 (P<0 .0 0 0 1)。多元逐步回归分析结果表明年龄、收缩压和心率是与反映大动脉弹性的PWV关系最为密切的参数 (P<0 .0 0 1)。结论　长期高血压将导致大动脉扩张性降低 ,这种改变随年龄增大而加重。年龄、收缩压、心率与高血压患者大动脉扩张性变化关系密切。Objective To explore the change in and factors influencing distensibility of large arteries in patients with essential hypertension of different age groups.Methods Automatic pulse wave velocity(PWV) measuring system was applied to examine carotid-femoral PWV as an index reflecting distensibility of large arteries.1?392 hypertensive patients aged 14～85(mean age 52.09±12.37) years were included in the study.Of them,954 were males and 438 were females.Results PWV of 1?392 hypertensive patients increased with increasing age(both in males and females,P<0.0001).Mutivariate regressive analysis demonstrated that age,systolic blood pressure and heart rate had close relationship with PWV(P<0.001).Conclusions Long-term hypertension could cause reduction of distensibility of large arteries.The older the age,the worse the distensibility of large arteries.Age,systolic blood pressure and heart rate had close relationship with distensibility of large arteries in patients with essential hypertension.

关 键 词：脉搏波速度 高血压 动脉扩张性 血管病变 

分 类 号：R544.1[医药卫生—心血管疾病]