一种微生物来源的白细胞介素1受体拮抗剂——多糖139A的化学结构研究  

STUDY ON THE STRUCTURAL PROPERTY OF POLYSACCHRIDES 139A A KIND OF IL-1R ANTAGONISTS FROM MICROORGANISM

作　　者：陈晶[1] 吴剑波[1] 刘叶民[2] 徐桂芸[2] 

机构地区：[1]中国医学科学院,中国协和医科大学医药生物技术研究所,北京100050 [2]中国科学院化学研究所,北京100080

出　　处：《药学学报》2001年第10期787-789,共3页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目 ( 396 70 0 16 )

摘　　要：AIM To study the structural property of the bioactive component from the fermentation broth of Streptomyces 139 which can inhibit IL 1R. METHODS Polysaccharide 139A is extracted and purified by means of macroreticular resin Diaion HP 20, cation exchange and DEAE Sephadex A 25 chromatography. The sugar compositions were analyzed with GC, the linkage positions of 139A were determined by methylation and GC MS. RESULTS The bioactive component which can inhibit IL 1R is a kind of polysaccharides. CONCLUSION The components of 139A repeat units are conjectured.AIM To study the structural property of the bioactive component from the fermentation broth of Streptomyces 139 which can inhibit IL 1R. METHODS Polysaccharide 139A is extracted and purified by means of macroreticular resin Diaion HP 20, cation exchange and DEAE Sephadex A 25 chromatography. The sugar compositions were analyzed with GC, the linkage positions of 139A were determined by methylation and GC MS. RESULTS The bioactive component which can inhibit IL 1R is a kind of polysaccharides. CONCLUSION The components of 139A repeat units are conjectured.

关 键 词：白细胞介素1 受体拮抗剂 多糖139A 化学结构 

分 类 号：R977.6[医药卫生—药品]