Pax-6基因在发育中的表达与动物眼的进化  

Developmental Expression of Pax-6 Gene and Eye Evolution

作　　者：乌日琴[1] 徐永立[1] 张培军[1] 

机构地区：[1]中国科学院海洋研究所实验海洋生物学开放实验室,青岛266071

出　　处：《动物学杂志》2002年第1期86-89,共4页Chinese Journal of Zoology

基　　金：中国科学院海洋研究所实验海洋生物学开放室基金资助

摘　　要：近年在脊椎动物和无脊椎动物中分离出Pax 6基因及其同源基因 ,这些基因都与动物的眼与神经系统的发育和形态发生有关。本文着重比较了无脊椎动物果蝇、文昌鱼、哺乳动物小鼠和人的Pax 6基因编码蛋白 ,Pax 6基因在发育过程中的表达 ,Pax 6与眼进化的关系等几个方面 ,并介绍Pax 6基因为靶基因的转基因果蝇的上游制作技术和原理。探讨了Pax 6基因作为眼发育的主导基因的作用和时空表达模式的保守性。Pax-6 genes have been identified from a broad range of invertebrate and vertebrate animals and have been shown to be always involved in the development of early eyes and neural system. In this review we emphasize on the comparison of Pax-6 gene encoding transcription factors, and its expression in the developing nervous system and in the eye during morphogenesis, and the relationship between eye evolution and Pax-6 gene in different animals. We have also discussed the upstream technique for producing transgenetic drosophila with ectopic eyes by targeted expression of eyeless gene, and conservation of the temporal and spatial expression patterns of Pax-6 gene.

关 键 词：Pax-6基因 Smalleye基因 eyeless基因 文昌鱼 发育 眼 进化 基因表达 动物 

分 类 号：Q344[生物学—遗传学]