盐酸沙拉沙星在鸡体内的药代动力学及残留的研究  

Studies on pharmcokinetics and residues of Sarafloxacin Hydrochloride in chickens

作　　者：李艳华[1] 佟恒敏[2] 赵晶[3] 阎清波[2] 

机构地区：[1]中国农业科学院哈尔滨兽医研究所,黑龙江哈尔滨150001 [2]东北农业大学动物医学院药理教研室,黑龙江哈尔滨150030 [3]哈尔滨师范大学,黑龙江哈尔滨150000

出　　处：《中国兽医杂志》2001年第7期3-5,共3页Chinese Journal of Veterinary Medicine

摘　　要：为研究盐酸沙拉沙星在蛋鸡体内组织动力学与残留 ,选用成年健康蛋鸡 95只进行试验。按 10 m g/ kg体重口服给药 ,给药后定期采样 ,测定血清及心、肝、肾、肌肉中盐酸沙拉沙星的含量。结果表明 :盐酸沙拉沙星在血液中经时过程符合一级吸收一室模型 ,主要动力学参数 t1 / 2 k3.793h、tmax1.5 80 7h、cmax0 .742 9μg/ m l、AU C5 .3790 μg/ ml.h。心脏、肾脏符合一级吸收三项指数方程 ,主要动力学参数分别为 t1 / 2 B7.76 5 h、40 .2 6 h,t1 / 2 a1.6 0 2 7h、4.418h、tmax1.6 82 6 h、1.985 5 h、cmax0 .5 12 9μg/ m l、0 .90 90μg/ m l,AU C9.0 2 6 5、10 .894μg/ ml.hμg/ m l.h。肝脏、肌肉符合一级吸收二项指数方程 ,主要动力学参数分别为 t1 / 2 k3.15 87h、4.12 4h,tmax1.976 4h、3.5 6 79h,cmax3.737μg/ m l、0 .6 95 6 μg/ ml,AU C31.35 4μg/ ml.h、5 .32 6 9μg/ m l.h。盐酸沙拉沙星在蛋鸡体内残留为 7天。chickens were selected to study pharmacokinetics and residues of Sarafloxacin Hydrochloride.Pharmacokinetics showed that the blood concentration time course could be described with the first compartment open model with the first order absorption after oral administration(10 mg/kg).It's main pharmacokinetics parameters were Ka 1.6025 h -1 、t max 1.5807 hrs、c max 0.7429 μg/ml、AUC5.3790 μg/ml.h.The heart and kidney concentration time date of Sarafloxacin Hydrochloride were best described by a triexponential equation with the first order absorption.Their main pharmacokinetics paramters were t 1/2B 7.765hrs、40.26hrs,t 1/2α 1.6027hrs、4.418hrs、t max 1.6826hrs、1.9855hrs、c max 0.5129 μg/ml、0.9090 μg/ml,AUC9.0265、10.894 μg/ml.h.The liver and muscle concentration time data of Sarafloxacin Hydrochloride were best described by a biexponential equation with first order absorption.Their main pharmacokinetics parameters were t 1/2k 3.1587hrs、4.124hrs,t max 1.9764hrs、3.5679hrs,c max 3.737 μg/ml、0.6956 μg/ml,AUC31.354 μg/ml.h、5.3269 μg/ml.h.The residues of Sarafloxacin Hydrochloride in chickens were 7 days.

关 键 词：盐酸沙拉沙星 鸡 药物代谢动力学 药物残留 抗菌素 

分 类 号：S859.796[农业科学—临床兽医学] S858.31[农业科学—兽医学]