心房钠尿因子对豚鼠窦房结自律性的影响  

EFFECT OF ATRIAL NATRIURETIC FACTOR ON THE AUTOMATICITY OF SINUS NODE IN GUINEA PIG HEART

作　　者：王庆山[1] 孙伟[1] 王德宝[1] 葛赋贵[1] 

机构地区：[1]张家口医学院生理教研室

出　　处：《生理学报》1991年第3期302-305,共4页Acta Physiologica Sinica

摘　　要：用微电极技术研究表明,分别灌流心房钠尿因子(ANF)0.025和0.05μmol/L 7min 后,豚鼠窦房结细胞的自发节律无明显变化,而用0.1μmol/L 灌流时,其自发节律明显降低7%(P<0.01)。但当上述三种浓度 ANF 和异丙肾上腺素混合液灌流时,自发节律分别降低4,12和22%。这些结果表明,ANF 能抑制异丙肾上腺素的阳性变时效应。其机理可能与 ANF 阻滞窦房结细胞的 T 型钙通道电流有关。The effect of atrial natriuretic factor(ANF)on sinoatrial(SA)node cells inguinea pig heart was studied by using intracellular microelectrodes.When theheart superfused with ANF 0.025 and 0.05 μmol/L for 7 min respectively,thespontaneous rate showed no significant changes,but 0.1 μmol/L ANF resulted ina definite decrease by 7%(P<0.01).However,when ANF(0.025,0.05 and0.1 μmol/L)was superfused along with 0.5 μmol/L isoproteronol,the sponta-neous rate was respectively depressed by 4,12 and 22% These results indicatethat ANF can depress the positive chronotropic effect of isopoterenol.The me-Chanism of this action may be related to the blocking effect of ANF on T-type cal-cium channel of SA node.

关 键 词：心房钠尿因子 窦房结 

分 类 号：R972[医药卫生—药品]