锌对小鼠免疫功能的影响  

EFFECT OF ZINC ON IMMUNE FUNCTION IN NORMAL MICE

作　　者：张晓华[1] 王龙[1] 董再珍 

机构地区：[1]山东大学生物学系,济南250100

出　　处：《生理学报》1991年第4期383-388,共6页Acta Physiologica Sinica

摘　　要：每天给小鼠0.2 mg 锌灌胃,连续15d,明显提高外周血 T 淋巴细胞百分率,促进 T淋巴细胞转化功能及迟发型超敏反应;对腹腔巨噬细胞吞噬功能有抑制作用、对 IgM 抗体生成及胸腺重量无明显影响。胸腺组织结构在光镜下未见明显变化,但在电镜下可见皮质淋巴细胞核形态有不规则变形。这些结果表明:一定剂量的锌对细胞免疫虽有促进作用,但对巨噬细胞吞噬功能有抑制作用,对胸腺淋巴细胞有潜在的损伤。Swiss mice were used for studying the effects of zinc on the immune functionand on the structure of thymus.The experimental results showed that:1)When mice were administered with a dose of zinc 0.2mg/d of mouse for 15d,the number of mature T lymphocyte in peripheral blood increased significantly,the transformation of lymphocytes and DTH response were both markedly en-hanced;phagocytosis of peritoneal macrophage was suppressed,but the productionof IgM and the weight of thymus were not affected.2)The shape of lymphocyte nucleus of the thymus cortex became irregularby administration of zinc.So,a certain immunity promotive dose of zinc mayimpose a latent injury to the lymphocyte of thymus.

关 键 词：免疫功能 锌 小鼠 胸腺 

分 类 号：R392.12[医药卫生—免疫学]