心房钠尿肽(ANP)对大鼠卵巢细胞生成雌激素与孕激素的影响  

EFFECT OF ANP ON ESTRADIOL AND PROGESTERONE PRODUCTION BY RAT OVARIAN CELLS

作　　者：赵玉莲[1] 王京花[1] 程治平[1] 

机构地区：[1]哈尔滨医科大学生理教研室,哈尔滨150086

出　　处：《生理学报》1991年第6期580-583,共4页Acta Physiologica Sinica

摘　　要：应用大鼠卵巢黄体细胞、颗粒细胞培养以及放射免疫分析法,观察了α型心房钠尿肽(α-ANP)对性甾体激素孕酮(P)和雌二醇(E_2)分泌的影响,结果发现,0.1—10ng/ml 浓度的α-ANP 促进离体培养的大鼠黄体细胞分泌孕酮,并呈量效关系。α-ANP 也促进大鼠卵泡颗粒细胞分泌孕酮,但对分泌雌二醇没有影响。说明α-ANP 也影响卵巢分泌功能。Isolated ovarian corpus luteal ceils and granulosa cells of rat were employedto investigate the effect of α-ANP on the secretion of progesterone and estradiol.The contents of the steroid hormones are determined by RIA.The results showedthat 0.1—10 ng/ml ANP promoted progesterone production in a dose depend-ent manner.α-ANP also enhanced progesterone production by granulosa cells,but not estradiol.It seems that the effect of α-ANP on ovarian steroidogenesisis a direct one.

关 键 词：卵巢细胞 雌激素 孕激素 ANP 

分 类 号：R339.22[医药卫生—人体生理学]