肝素盐水间断静脉推注预防化疗性静脉炎的效果观察  

Therapeutic Effects of Heparin Saline Discontinuous Intravenous Injection in the Prevention of Chemotherapyin-duced Phlebitis

作　　者：陈岱佳[1] 谢德荣[1] 谢雪霞[1] 陈丽容[1] 梁佩仲[1] 吴琛[1] 陈紫玲[1] 

机构地区：[1]中山医科大学孙逸仙纪念医院肿瘤科,广州510120

出　　处：《护理学杂志（综合版）》2002年第2期109-110,共2页Journal of Nursing Science

摘　　要：目的降低大肠癌病人大剂量醛氢叶酸 +氟尿嘧啶持续静脉滴注 48h所致静脉炎的发生率。方法将 5 5例晚期大肠癌病人随机分为对照组 2 0例和观察组 35例 ,对照组于持续滴注期间每 4h推注 0 .9%氯化钠注射液10 ml,拔针前再推注 2 0 ml冲管。观察组于持续滴注期间每 4h推注肝素盐水稀释液 (肝素钠 12 5 0 0 U +0 .9%氯化钠注射液 2 5 0 ml) 10 m l,拔针前推注 2 0 ml冲管。结果观察组静脉炎发生率 2 5 .7% (9/ 35 ) ,对照组 90 .0 % (18/ 2 0 ) ,两组比较 ,χ2 =2 1.0 46 ,P<0 .0 1,差异有极显著性意义 ;观察组未发生 、 度静脉炎。结论肝素盐水稀释液能有效降低大剂量醛氢叶酸 /氟尿嘧啶持续滴注 48h所致静脉炎的发生率 ,减轻静脉炎的严重程度。Objective To reduce the incidence of phlebitis induced by the continuous injection of high dose of Calcium Folinate plus 5 Fluorouracil for 48 h. Methods Fifty five cases of advance colorectal carcinoma were randomly divided into control group ( n =20) and observation group ( n =35). The patients in the control group received intravenous injection of normal saline in an interval of 4 h during continuous injection, while those in the observation received the intravenous injection of heparin saline solution (heparin sodium 12 500 U plus 0 9 % sodium chloride 250 ml) in an interval of 4 h during continuous injection. Results The incidence of phlebitis in the observation group and control group was 25 7% and 90% respectively ( P <0 01). No Ⅲ and Ⅳ phlebitis occurred in the observation group. Conclusion Heparin saline solution could effectively reduce the incidence of phlebitis induced by continuous intravenous injection of high dose of Calcium Folinate plus 5 Fluorouracil for 48 h and alleviate the severity of phlebitis.

关 键 词：大肠癌 氟尿嘧啶 静脉推注 肝素盐水 化疗性静脉炎 临床疗效 

分 类 号：R543.6[医药卫生—心血管疾病] R730.53[医药卫生—内科学]