肠安胶囊治疗溃疡性结肠炎32例临床研究  

Clinical study on treatment of 32 cases of ulcerative colitis with Chang An Capsules

作　　者：刘万里[1] 沈洪[2] 单兆伟[2] 朱云华[2] 周晓白[2] 邵家德[2] 

机构地区：[1]南京中医药大学研究生部,南京市汉中路282号210029 [2]南京中医药大学附属医院

出　　处：《中医杂志》2002年第2期119-120,共2页Journal of Traditional Chinese Medicine

基　　金：江苏省中医管理局资助项目(97027);江苏省卫生厅333人才工程资助项目;江苏省科委指导项目(BS97375)

摘　　要：目的:探讨肠安胶囊对溃疡性结肠炎的治疗作用及机理。方法:将62例溃疡性结肠炎患者随机分为两组,分别给予肠安胶囊、补脾益肠丸口服,疗程均为3个月。观察临床、病理疗效,治疗前后肠镜征象、血清免疫球蛋白、补体C_3、血清超氧化物歧化酶(SOD)、过氧化脂质(LPO)的变化。结果:治疗组临床总有效率为93.80％,肠镜、病理疗效分别为81.30％、84.40％,对血清免疫球蛋白、补体C_3、SOD、LPO也有明显的改善和阻抑作用,与对照组比较有显著性差异(P<0.05或P<0.01)。结论:说明肠安胶囊对溃疡性结肠炎有显著的治疗作用,其机理可能与抑制结肠粘膜损伤,促进溃疡修复,增强机体清除自由基和抗氧化能力,调节免疫机能有关。In order to explore the therapeutic action and mechanisms of Chang An Capsules for treatment of ulcerative colitis, 62 cases were randomly divided into two groups and treated with oral administration of Chang An Capsules and Bu Pi Yi Chang Pill respectively, for 3 therapeutic courses. Clinical observation, pathological therapeutic effects, and changes of enteroscopic sign , serum immunoglobin, complement C3, serum superoxide dismutase (SOD) and lipid peroxide (LPO) before and after treatment were observed. Results indicated that in the treatment group, the total effective rate was 93. 80%, the therapeutic effects for enteroscopy and pathology were 81. 30% and 84. 40% respectively, and serum immunoglobin, complement Cs, serum superoxide dismutase (SOD) activity and lipid peroxide (LPO) were improved or inhibited, with significant difference compared with the control group (P < 0. 05 or P<0. 01). It is suggested that Chang An Capsules has an obvious therapeutic action, and its mechanism is possibly related with inhibition of lesion of intestinal mucosa. promotion of ulcerative repair, strengthening of removing free radicals and anti ?oxidation abiliity, and regulation of immunological function.

关 键 词：溃疡性结肠炎 中医药疗法 肠安胶囊 作用机理 

分 类 号：R259.7[医药卫生—中西医结合]