丹参、甘露醇对肢体缺血再灌注所致肺损伤保护作用的比较  

PROTECTIVE EFFECTS OF RADIX SALVIA MILTIORRHIZA AND MANNITOL ON LUNG INJURY AFTER LOWER LIMB ISCHEMIC REPERFUSION

作　　者：陈建常[1] 王乐农[1] 史振满[1] 卢开柏[1] 

机构地区：[1]兰州军区乌鲁木齐总医院全军骨科中心,830000

出　　处：《中国现代医学杂志》2001年第11期12-13,共2页China Journal of Modern Medicine

基　　金：兰州军区资助课题

摘　　要：目的 :通过动物实验方法观察丹参、甘露醇对肢体缺血再灌注所致肺损伤的保护作用。方法 :16 0只Wis tar大鼠随机分成正常对照 ,缺血 3h ,缺血 3h用丹参和甘露醇 4个组。实验组于缺血、再灌注 1、2、3和 2 4h取材 ,光镜下对比观察和组织学评估。结果 :肢体缺血和再灌注后 ,实验组肺泡隔增厚、水肿 ,毛细血管扩张、充血、大量多核白细胞浸润、贴壁 ,部分肺不张。用丹参和甘露醇组的病理改变明显轻于未用丹参和甘露醇组。结论 :丹参和甘露醇都能有效地减轻肢体缺血再灌注所致的肺损伤。Objective:To observe protective effects of Radix Salvia Miltiorrhiza(RSM)and Mannitol on lung injury after lower limb ischemic reperfusion.Methods:One hundred and sixty rats were divided into control group,ischemia 3 hours group and ischemia 3 hours group treated with RSM or Mannitol.The histological assessment of lung was undertaken at 0,1,2,3,and 24 hours after reperfusion.Results:Pulmonary edema,microvascular congestion,infiltration of larg amount of polymorphonuclear neutrophil(PMN) and partial pulmonary collapse were found in experimental group at 0,1,2,3,and 24 hours after reperfusion.However,pulmonary injury of animals treated with RSM and Mannitol was markedly attenuated compared with animals without treating.Conclusions:RSM and Mannitol can alleviate pulmonary injury after lower limb ischemic reperfusion.

关 键 词：丹参 甘露醇 肢体 缺血再灌注 肺损伤 保护 

分 类 号：R285.5[医药卫生—中药学] R259.63[医药卫生—中医学]