两种慢性痛大鼠脊神经节生长抑素mRNA的表达及电针的影响  

EXPRESSION OF SOMmRNA IN RATS' DRG IN TWO KINDS OF CHRONIC PAIN MODELS AND THE EFFECT OF ELECTRONIC ACUPUNCTURE

作　　者：田占庄[1] 张丽凤[2] 朱培纯[3] 陈浩[3] 许红[3] 吴海霞[3] 

机构地区：[1]承德医学院解剖教研室,河北承德067000 [2]承德医学院附属医院 [3]北京中医药大学解剖教研室

出　　处：《承德医学院学报》2001年第4期267-271,共5页Journal of Chengde Medical University

基　　金：国家自然科学基金资助课题

摘　　要：目的 :观察福尔马林试验和去传入神经两种慢性痛模型大鼠脊神经节生长抑素 m RNA的改变。方法 :原位杂交组织化学。结果 :福尔马林试验可导致大鼠同侧脊神经节生长抑素 m RNA阳性细胞增加 ,而去传入神经则导致大鼠双侧脊神经节生长抑素 m RNA阳性细胞减少。结论 :电针可以分别改变两种模型大鼠脊神经节生长抑素 mObjective:A large of experiments founded that neurochemical changes are different between formalin test and neuropathic pain represented by deafferentation.Methods:In this study we used in situ hybridization histochemistry to investigate the expression of SOMmRNA in the two kinds of pain models.Results:The effects of electronic acupuncture on the experession of SOMmRNA were studied.The results showed that the number of SOMmRNA positive cells in DRG were increased in formalin test group.The number of SOMmRNA positive cells in DRG were decreased after deafferentation.Conclusion:An electronic acupuncture can change the both expression of two kinds of chronic pain models.

关 键 词：传入神经 脊神经节 原位杂交 生长抑素MRNA 电针 疼痛 

分 类 号：R338.3[医药卫生—人体生理学] R245.97[医药卫生—基础医学]