发育中小鼠和鸡胚脑微管蛋白的合成与甲状腺功能间的关系  

THE RELATION BETWEEN THE BRAIN TUBULIN SYNTHESIS AND THYROID FUNCTION IN THE DEVELOPING MICE AND THE CHICK EMBRYOS

作　　者：郭守祥[1] 崔汝珍 卢少杰 李兰戈 

机构地区：[1]天津医学院生化教研室,天津300070

出　　处：《生物化学与生物物理进展》1991年第5期365-368,共4页Progress In Biochemistry and Biophysics

摘　　要：利用~3H-秋水仙碱与微管蛋白间的特异结合及DEAE纤维素对微管蛋白的离子交换作用,连续测定小鼠、鸡胚脑发育过程中的脑微管蛋白的合成变化。结果表明脑微管蛋白的合成速度均在其脑发育的临界期时达到最高峰。此时恰是甲状腺功能逐渐完善的时期。当小鼠进入育龄期时,雌雄鼠脑微管蛋白含量差异显著。可能说明性激素对微管蛋白的合成有重要影响。Using the specific affinity of tubulin for colchincine and the strong absorption of tubulin to DEAE ion exchangers at neutral pH and moderate ionic strength, the tubulin amounts in the brain from both mice and chicks in different developing stage was quantitated by ~3H-colochicine assay (expressed as colchicine binding activity). The results showed that the rate of tubulin synthesis was a peak value period in the brain developing critical period This is exactly a period in which thyroid organization and function are being perfected. Besides, in breeding period, the difference of tubulin content between male and female is significan (P<0.001). The tubulin synthesis is strictly sex dependent (only brain from sex maturity stage). We suggested that the sexual hormone might exert their effect in tubulin synthesis.

关 键 词：脑 微管蛋白 合成 甲状腺 发育 

分 类 号：Q593[生物学—生物化学]