动态血压监测多方法同时比较评价依那普利降压疗效  

Evaluation of Antihypertensive Effects by Enalapril with Multi-Method of ABPM

作　　者：刘勇[1] 陈家香[2] 陈运贞[2] 罗素新[2] 

机构地区：[1]四川省自贡市第三人民医院心内科,四川自贡643020 [2]重庆医科大学附一院心内科

出　　处：《高血压杂志》2001年第4期305-307,共3页Chinese Journal of Hypertension

摘　　要：目的　用动态血压评价依那普利降压疗效并进行总体疗效判断和 4种判效方法学比较。方法　对 5 8例严格选择的轻 -中度高血压病人用依那普利单盲法治疗前后比较动态血压和偶测血压结果 ,并进行A、B、C、D 4种方法比较。结果　A法降压总有效率 89 6 %、B法 79 3%、C法 72 5 %、D法 6 7 2 % ;判断一致性 (K值 )在A与B、C、D之间分别为 0 11、0 0 4、0 18(P值均 >0 0 5 ) ,B与C或D之间分别为 0 44 (P <0 0 5 )、0 33(P >0 0 5 )、C与D间为 0 6 8(P <0 0 1) ;平均特异性和敏感性分别为A法 16 4%和 92 5 %、B法 41 1%和 87 5 %、C法 5 6 7%和84 2 %、D法 73 6 %和 77 3%。结论　依那普利中小剂量晨起一次性给药 4周后能平稳降低全天血压 ,但有效率判断方法中不同方法有不同效果 。Objective To observe the antihypertension effect with enalapril and compare the results with different evaluation methods(A,B,C,D) Methods ABPM were performed before and after treatment with enalapril (10 to 15 mg per day) by single blind study in 58 mild moderate hypertensions for 4 w According three kind of ABPM judgement and CBP ordinary method(A) to analyse the efficacy of enalapril. Results The total response rate(%) of antihypertensive therapy judged by method A?B?C?D were 89 6%?79 3% ?72 5% ?67 2% respectively; The kappa values in comparing A to B,C or D were 0 11,0 04,0 18, respectively and all were no statistic difference( P >0 05), B to C or D were 0 44 ( P <0 05),0 33 ( P >0 05), C to D was 0 68 ( P <0 01). Specificity and sensitivity of method A were 16 4% and 92 5%,B 41 1% and 87 5%, C 56 7% and 84 2%, D 73 6% and 77 3%,respectively Conclusions Enalapril adiministrated once daily at morning could reduce BP smoothly throughout 24 hours, but different effect rate depends upon the relevant judge method , we believe D method be the best

关 键 词：动态血压监测 依那普利 降压疗效 方法学 治疗 

分 类 号：R972[医药卫生—药品]