四种中草药对大鼠半乳糖性白内障相关酶活性的影响  

Effect of Four Chinese Medicinal Herbs on Enzyme Activities of Rat Lens of Galactose Induced Cataract

作　　者：杨涛[1] 梁康[1] 侯纬敏[1] 张昌颖[1] 

机构地区：[1]北京医科大学生化教研室,北京100083

出　　处：《生物化学杂志》1991年第6期731-736,共6页

基　　金：国家教委博士点基金;国家自然科学基金

摘　　要：本实验测定了中草药对大鼠半乳糖性白内障延缓及治疗中五种酶活性的影响。结果表明,在白内障晶状体中,醛糖还原酶的活性明显升高;多元醇脱氢酶,己糖激酶,6磷酸葡萄糖脱氢酶及过氧化氢酶的活性明显降低。在注射半乳糖的同时,分别用黄芩、石斛、菟絲子及玉蝴蝶四种中草药水煎剂灌胃,醛糖还原酶的活性没有明显升高,其余四种酶的活性均基本恢复到正常,表明这四种中草药对半乳糖所致的酶活性异常变化有抑制或纠正作用。The activities of five enzymes in lenses of normal rats, and ratss with galactose induced cataract or galactose cataract feeded with Chinese medicinal herbs were studied. Results showed that in the lenses of galactose cataract, the activity of aldose reductase increased significantly, those of polyol dehydrogenase, hexokinase, 6-phosphate glucose dehydrogenase and catalase decreased. When the decoctions of Scutellaria baiaalensis G.,Dendrobium nobile Lindl, Cuscuta chinesis Lam and Orox-yleum indicum Vent were seperately given to treated rats by intragastric administration at the sametime of galactose induction, the activity of aldose reductase did not increase significantly in the lenses and those of polyol dehydrogenase, hexokinase, 6-phosp-hate glucose dehydrogenase and catalase remained nearly at the normal levels. Thus, it is obvious that the four Chineses medicinal herbs can more or less prevent the abnormal changes in activity of certain enzymes which are concerned in the carbohydrate metabolism or oxidation system of lens, and thus delay the formation of cataract induced by galactose.

关 键 词：白内障 半乳糖性 中草药 酶活性 

分 类 号：R276.761[医药卫生—中医五官科学]