云南省血吸虫病中度流行区筛检化疗方案效果研究  

The study on Effectiveness of two chemotherapy strategies in moderately Epidemic Areas of Schistosomiasis Japanica in Yunnan mountainsarea

作　　者：罗天鹏 连自强 李炳桂 李伟枢 杨文胜 方翠 高灿雄 张灿钟 

机构地区：[1]云南省血吸虫病防治研究中心,中国云南大理671000 [2]云南省鹤庆县血吸虫病防治站,中国云南鹤庆671500

出　　处：《实用预防医学》2001年第5期321-322,共2页Practical Preventive Medicine

基　　金：JRMC资助课题部分内容 课题编号J7- 5

摘　　要：目的　比较实施每年 30 %和 5 0 %人群筛检化疗两种方案的费用与效果 ,提出控制疾病的优化化疗方案。　方法　在鹤庆县的古乐和新庄两行政村中 ,选择 12个自然村 ,随机分为A、B两组。A组每年对 6～ 6 0岁人群用间接血凝试验 (IHA)筛检 30 % ,连续 3年 ;B组每年筛检 5 0 % ,连续 2年 ;IHA≥ 1∶10者用吡喹酮化疗。分析两方案的费用与效果。　结果　A组居民感染率下降率、病人感染率下降率、人群感染率下降率、钉螺自然感染率下降率、感染螺密度下降率分别为 45 37%、14 5 4%、36 79%、2 9 6 7%、9 5 2 % ;B组上述指标分别为 39 81%、15 49%、2 3 91%、10 0 0 %、3 5 4%。　结论　两种筛检化疗方案均可作为中度疫区控制疾病的防治方案 ,其效果以每年筛检 30Objective To compare the effectiveness of two chemotherapy strategies in moderately epidemic area of Schistosomiasis Japanica in Yunnan mountainsarea. Methods 12 natural villages in Heqing County, chosen with midding prevalence of Schistosomiasis Japanica, were divided random into two groups: A and B. The 30% of residents who are 6～60 years old in A group were screened by IHA for 3 years. 50% of residents in B group were screened for 2 years. The persons whose IHA≥1∶10 have been treated annually with praziquantel. Result In group A, the reductions of infected rate for 6～60 aged population, 6～14 aged children are 45.37%,43.02%, and group B are 39.81%,51.14%, respectively. Conclusion Both screening-chemotherapy schemes can reduce infective rate of schistosomiasis in human. But A scheme is better.

关 键 词：血吸虫病 筛检化疗 流行病学 云南 

分 类 号：R532.210.5[医药卫生—内科学]