健骨冲剂对去卵巢大鼠股骨及腰椎的生物力学作用  

Biomechanical effects of Jiangu Chongji(a TCM decoction) on femur and lumbar vertebrae of ovariectomy female rats

作　　者：王晓达[1] 张风华[1] 符诗聪[1] 史炜镔[1] 杜宁[1] 李国衡[1] 

机构地区：[1]上海第二医科大学附属瑞金医院,上海200025

出　　处：《中国骨伤》2001年第10期601-603,共3页China Journal of Orthopaedics and Traumatology

基　　金：上海市科委基金资助项目 (合同编号 :9741 1 90 35)

摘　　要：目的　研究不同剂量健骨冲剂预防去卵巢 1月后SD大鼠生物力学特性降低的疗效。方法　 77只 6月龄雌性SD大鼠随机分为 7组 :假手术 (Sham)组、卵巢切除 (OVX)组、尼尔雌醇 (E)组、仙灵骨葆 (X)组、健骨冲剂低剂量 (JL)组、健骨冲剂高剂量 (JH)组、健骨冲剂中剂量 (JM )组 ,每组 11只 ;除Sham组外 ,其余各组行卵巢摘除术诱导绝经后骨质疏松症模型 ,术后除OVX组各治疗组分别给药 ,1月后测定生物力学指标。结果　JH组股骨抗弯程度显著高于OVX组 ,股骨中段直径显著小于后者 ;JM组腰椎抗压强度显著高于OVX组 ;3种剂量组股骨弹性模量和椎体直径显著高于E组 ,腰椎抗压强度均显著低于后者。结论　低、中剂量健骨冲剂短期应用能够预防OVX术大鼠骨折危险性增加的趋势。Objective To study the biomechanical effect with different dosage of Jiangu Chongji(JC) on ovariectomy SD rats Methods 77 female SD rats at 6 months were randomly divided into 7 groups of 11 each:Sham group,OVX group,E group,X group,JL group,JH group,JM group.All the animals had ovariectomy except those in the Sham group and treated 1 month seperatly except OVX group.The biomechanical index of femur and lumbar vertebrae of ovariectomy female rats were measured after 1 month.Results The mechanical strength and diameter of the femur in low dose group were significantly higher than that of OVX group and diameter of the femur smaller than latter;the lumbar vertebrae compressive strength in middle dose group were higher,and the modulus of elasticity of the femur and diameter of the lumbar vertebrae in the 3 JC groups were signficantly higher than that of the estrogen group and the lumbar vertebrae compressive strength were lower than the latter.Conclusion JC appears to be able to prevent increasing risk of fracture in ovariectomized rats.

关 键 词：补肾药 骨质疏松 绝经后 生物力学 中医药疗法 

分 类 号：R274.91[医药卫生—中西医结合]