椎动脉阻断对小脑后下叶功能影响的实验研究  

An experimental study on function of posterior inferior lobe of cerebellum after ligation of vertebrae artery bilaterally

作　　者：何海龙[1] 贾连顺[1] 李家顺[1] 孔庆毅[1] 纪荣明[2] 余科炜[1] 

机构地区：[1]第二军医大学附属长征医院骨科,上海凤阳路415号200003 [2]第二军医大学解剖教研室

出　　处：《中国脊柱脊髓杂志》2002年第1期23-26,共4页Chinese Journal of Spine and Spinal Cord

基　　金：上海市科技发展基金资助课题 基金编号 0 0 41190 12

摘　　要：目的 :研究双侧椎动脉阻断后对小脑后下叶组织功能的影响。方法 :结扎犬双侧C4、C5椎动脉 ,分别于术后1d、7d、2 8d观察行为、影像学和细胞形态学的变化 ,并对小脑后下叶毛细血管灌注作定量分析。结果 :术后 1d组动物出现轻度缺血性损害 ,7d组及 2 8d组均未见异常。结论 :双侧椎动脉血流阻断不会引起椎动脉供血区域慢性缺血性损害。Objective:To study the impact on posterior inferior lobe of cerebellum function after bilateral ligation of vertebrae artery.Method:The animals were divided into 4 groups by which were sacrificed the 1st,7th,28th day postoperatively and the other served as control group.Ligation of vertebrae artery was performed at C4,C5 segment bilaterally.Behavior,image,histology,and microangiography analysis were performed.Result:Except minimal ischemic injury were found in the 1st group,other animals all were normal.Conclusion:Blood obstruction of the vertebrae artery bilaterally would not lead to chronic ischemic injury of the corresponding area.Cerebral ischemia by compression of the vertebrae artery were not the main pathomechanism of Cervical Spondylotic Arteriopathy(CSA).

关 键 词：椎动脉型颈椎病 椎动脉阻断 脑组织功能 动物实验 

分 类 号：R681.55[医药卫生—骨科学] R331.33[医药卫生—外科学]