米非司酮对离体异位子宫内膜细胞凋亡的影响  

Apoptotic influence of mifepristone for the isolated ectopic endometrium.

作　　者：王云霞[1] 李亚里[1] 黄靖香[1] 昝世明 

机构地区：[1]解放军总医院,北京100853

出　　处：《现代妇产科进展》2002年第1期33-35,共3页Progress in Obstetrics and Gynecology

基　　金：国家自然科学基金资助课题 (39830 35 0 )

摘　　要：目的 :观察培养的异位子宫内膜细胞分组加入米非司酮后的生长情况及形态学变化 ,并检测其凋亡率 ,探讨子宫内膜异位症的药物治疗。方法 :对子宫内膜异位症14例的异位子宫内膜离体组织进行培养 ,在相同的生长期加入一定剂量米非司酮后 ,观察细胞的生长状况并用TUNEL法检测其凋亡率。结果 :加入米非司酮后 ,细胞生长速度减慢 ,其凋亡率较未用药组明显增加 ,差异有显著性 (P <0 .0 5 )。结论 :米非司酮对异位细胞有抑制作用 ,并诱导异位子宫内膜细胞凋亡 ,应用于临床治疗子宫内膜异位症疗效良好。Objective:To explore the drug treatment for mifepristone to endometriosis in vitro.Methods:The cells of isolated ectopic endometrium from 14 patients with endometriosis (EMs) were cultured.In the same growth term,mifepristone of different dosage were added,and the cells growth station was observed and their apoptotic rates were studied by TUNEL method.Results: The speed of cell growth was significantly decreased and the apoptotic rate was significantly increased compared with no mifepristone (P<0.05). Conclusions:Mifepristone can restrain the ectopic cells and induce the ectopic endometrium to apoptosis.Mifepristone plays an important role at the treatment for endometriosis in clinic.

关 键 词：子宫内膜异位症 异位细胞 米非司酮 细胞凋亡 

分 类 号：R711.71[医药卫生—妇产科学]