生物健对小鼠免疫功能的影响  

Effects of Shengwujian Oral Liquid on Immune Function in Mice

作　　者：林妮[1] 潘竞锵 肖柳英 张丹[1] 郑琳颖[1] 李博萍[1] 

机构地区：[1]广州市中医院药剂科,广东510130 [2]广州市中医中药研究所,广东510130

出　　处：《深圳中西医结合杂志》2001年第6期329-331,335,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的　研究生物健对小鼠体液免疫、细胞免疫、红细胞免疫和单核 -巨噬细胞系统的作用。方法　用正常小鼠、环磷酰胺 (CY)致免疫抑制和 2 ,4二硝基氟苯 (DNFB)诱导迟发型超敏反应 (DTH)小鼠模型 ,研究生物健对小鼠IgG和补体C3 含量、白细胞总数 (WBC)、红细胞免疫粘附、DTH作用和碳粒廓清能力等实验指标的影响。结果　生物健能提高正常和免疫抑制小鼠IgG和补体C3 含量 (P <0 .0 5 ) ;提高低白模型小鼠WBC数量 (P <0 .0 1) ;增强红细胞免疫粘附能力 (P <0 .0 1) ;增强碳粒廓清能力 (P <0 .0 1)和DNFB诱导DTH (P <0 .0 1)。结论　生物健能增强小鼠 (尤其是免疫抑制状态下 )体液、细胞免疫功能和非特异性的红细胞免疫粘附能力、碳粒廓清能力 。? Objective To investigate effects of Shengwujian oral liquid on humoral immunity,cellular immunity,red blood cell (RBC) immunity and macrophage-phagocyte system (MPS).Methods To observe the effects of Shengwujian oral liquid on serum IgG and complement C 3 content,white blood cell (WBC) count,RBC immune adhering function,2,4-dinitrofluorobenzene(DNFB)induced-delayed type hypersensitivity (DTH) and phagocytic ability of macrophage in either normal mice or cyclophosphamide (CY)-induced-immunosuppressed mice.Results Serum IgG and complement C 3contents were increased in normal and/or CY-induced-immunosuppredded mice (P<0.05);CY-induced-leucopenia was improved (P<0.01);RBC immune adhering function was enhanced (P<0.01);phagocytosis of macrophage was elevated (P<0.01);DNFB induced-DTH was potentiated (P<0.01).Conclusion Shengwujian oral liquid possesses a similar ability of a biological response modifier as levamisole.

关 键 词：生物健口服液 免疫功能 免疫增强作用 生物反应调节剂 动物实验 

分 类 号：R977[医药卫生—药品] R392－33[医药卫生—药学]