高血压并脑梗死患者肿瘤坏死因子水平变化与胰岛素抵抗的关系  

Relationship between tumor necrosis factor-α and insulin resistance in patients with hypertension complicated cerebral infarction

作　　者：黄继良[1] 武芳[2] 张欣然[1] 张国清[1] 王东华[1] 王柏川[1] 

机构地区：[1]河北张家口解放军第251医院 [2]张家口医学院第一附属医院,张家口07500

出　　处：《河南实用神经疾病杂志》2001年第6期8-9,共2页Henan Journal of Practical Nervous Diseases

摘　　要：目的 :为探讨高血压并脑梗死 (HCI)患者血清肿瘤坏死因子 -α(TNF -α)水平变化与胰岛素抵抗 (IR)的关系。方法 :采用氧化酶法、放免法和酶联免疫法分别测定 2 3例HCI患者 (A组 )、2 5例高血压患者 (B组 )、2 1例正常健康人 (C组 )的空腹血糖 (FBG)、空腹胰岛素 (FINS)及血清TNF -α值 ,并计算胰岛素敏感指数 (ISI)。结果 :A组与B组、C组比较显示 :FINS、TNF -α水平显著增高 ,而ISI显著降低。相关分析发现 ,TNF -α与ISI呈显著负相关 ,而与FINS呈显著正相关。结论 :HCI患者TNF -α水平增高 ,且与胰岛素抵抗并存 。Objective:To investigate the changes of tumor necrosis factor-α(TNF-α) with hypertension complicated cerebral infarction (HCI) and the relationship between TNF-α and insulin resistance(IR).Methods:23 patients with HCI (group A), 25 patients with hypertension (group B) and 21 healthy people (group C) were selected and fasting blood-glucose(FBG), fasting blood-insulin(FINS) and serum TNF-α were checked by oxidase method, RIA and ELISA, insulin sensitiveity index(ISI) was also calculated.Results:Analysis of variance revealed that FINS, TNF-α were significantly higher while ISI lower in group A than those in group B and group C. Correlation analysis showed that TNF-α was negatively correlated to ISI, and positively associated TNF-α and FINS.Conclusion:The study indicated that significantly higher level of TNF-α and IR played important role in the development of hypertension complicated cerebral infarction.

关 键 词：高血压 脑梗死 肿瘤坏死因子 胰岛素抵抗 并发症 

分 类 号：R544.106[医药卫生—心血管疾病] R743.33[医药卫生—内科学]