超广谱β-内酰胺酶的耐药性监测及方法的可行性研究  

Drug Resistance Analysis of Extended-spectrum β-Lactamase and Study of Its Feasible,Methods

作　　者：赵建平[1] 周秀岚[2] 燕成岭[1] 王文灏[1] 

机构地区：[1]内蒙古自治区医院检验科,内蒙古呼和浩特010017 [2]内蒙古医学院附属医院药剂科,内蒙古呼和浩特010050

出　　处：《内蒙古医学杂志》2001年第6期481-487,共7页Inner Mongolia Medical Journal

基　　金：内蒙古自治区自然科学基金资助项目 (2 0 0 0 1 3 0 6)

摘　　要：目的 :了解内蒙古地区ESBLs的发生率及耐药性 ,比较三种检测方法。方法 :纸片扩散初筛法、双纸片协同法、标准纸片扩散确认法。结果 :ESBLs总检出率为1 0 2 % ,双纸片协同法与确认法符合率达 97 3 % ,产ESBLs较非ESBLs株耐药性高。ESBLs株的耐药率 :IMP为 0 ;PIP/TAZ为 5 4% ;CFP/SU为 1 6 2 % ;FOX为 2 1 6 %。结论 :双纸片法简单易行 ,适合各级医院开展和推广。治疗ESBLs菌的感染 ,首选碳青霉烯类 ;对部分 β-内酰胺酶抑制剂复合物、头霉烯类有良好的作用。Objective:To investigate the incidence of ESBLs in Inner Mongolia Region and its drug resistance,and compare three detection methods.Methods:Disc diffusion screening method,double-disc synergy method,K-B disc diffusion confirmatory method.Results:The average detection rate of ESBLs was 10.2%,the coincidence rate between double-disc synergy test and confirmatory test was 97.3%,and the drug resistance of ESBLs producing was higher to the one of non-ESBLs.The drug resistance of ESBLs was 0,5.4%,16.2%,21.6%,respectively for Imipenem,piperacillin/tazobactam cefoperaxzone/subactam,cefoxitin.Conclusion:The double-disc method is conve nient to all kinds of hospitals.To cleal with the ESBLs strains,Carbapenems can be used;such antibiotics as.

关 键 词：超广谱Β-内酰胺酶 抗生素 耐药性 大肠埃希氏菌 克雷伯氏菌 肠杆菌 

分 类 号：R446.5[医药卫生—诊断学] R978.11[医药卫生—临床医学]