山莨菪碱与膜相互作用的小角X射线衍射研究  

THE SMALL ANGLE X-RAY DIFFRACTION FOR DETERMINING THE INTERACTION OF ANISODAMINE MOLECULES WITH MEMBRANE STRUCTURES

作　　者：徐育敏[1] 赵南明[1] 

机构地区：[1]清华大学生物科学与技术系

出　　处：《生物物理学报》1991年第3期289-294,共6页Acta Biophysica Sinica

基　　金：国家自然科学基金

摘　　要：应用小角X射线衍射和差示扫描量热法研究了中药提取物山莨菪碱与DPPC多层膜的相互作用.结果表明,山莨菪碱不仅能降低DPPC多层膜的相变温度,而且能使多层膜发生分相现象,根据衍射结果并采用推广傅里叶合成去卷积法计算了脂双分子层膜的电子密度剖面图.The interaction of anisodamine molecules (extracted from traditional Chinese medicine) with DPPC multilayer was studied by small angle x-ray diffraction and DSC technique. The result shows that anisodamine not only can decrease the temperature of phase transition, but also can induce the phase separation of DPPC multilayer. The electron density profile of lipid bilayer was calculated by Generalized Fourier Synthesis Deconvolution Methods (GFSDM). From the electron density profile we infer that the anisodamine molecules probably located at the inner side of the polar headgroup of the lipid bilayer.

关 键 词：山莨菪碱 生物膜 相互作用 

分 类 号：R912[医药卫生—药学]