Lys-2-rhTNFα及^(125)Ser-rhIL-2促进小鼠腹腔巨噬细胞的肿瘤杀伤活性的研究  

Antitumor Activity of Mouse Peritoneal Macrophages Stimulated by Lys-2-rhTNFα and ^(125)Ser-rhIL-2

作　　者：朱雪梅[1] 戴静芝[2] 刘全海[2] 

机构地区：[1]上海第二医科大学附属瑞金医院肺科,上海200025 [2]上海医药工业研究院,上海200437

出　　处：《中国医药工业杂志》2001年第7期304-306,共3页Chinese Journal of Pharmaceuticals

摘　　要：研究了 L ys- 2 - rh TNFα(1)及 1 2 5 Ser- rh IL- 2 (2 )对小鼠腹腔巨噬细胞杀伤肿瘤的促进作用。2单用能激活小鼠巨噬细胞对小鼠肥大细胞瘤 P815的细胞毒性 ,1单独无此作用 ,但与 2联合使用能促进 2对巨噬细胞的激活作用。腹腔非粘附细胞的存在是 2或 2联合The antitumor activity of mouse peritoneal macrophages stimulated by Lys 2 rhTNFα and 125 Ser rhIL 2 was investigated. 125 Ser rhIL 2 stimulated the antitumor activity of mouse peritoneal macrophages. Lys 2 rhTNFα alone did not show any activating effect, but when combined with 125 Ser rhIL 2, it could enhance the antitumor activity of macrophages. Nonadherent peritoneal exudate cells were required for the activation of macrophages.

关 键 词：重组人肿瘤坏死因子 重组人白介素-2 巨噬细胞 肿瘤 动物实验 

分 类 号：R961[医药卫生—药理学]