盐酸多奈哌齐的药效学与药动学  

on Donepezil Hydrochloride Pharmacodynamics Pharmacokinetics

作　　者：阴赪宏[1] 冯文华[2] 马辰[2] 

机构地区：[1]首都医科大学附属北京友谊医院 [2]中国医学科学院中国协和医科大学药物研究所

出　　处：《当代医学》2001年第12期58-62,共5页Contemporary Medicine

摘　　要：盐酸多奈哌齐是选择性较强的AchE抑制剂,其抑制作用是可逆的、非竞争性的,能够抑制动物体内的胆碱酯酶活性,改善学习障碍,是治疗早老性痴呆的有效药物。Donepezil hydrochloride, a selective acetylcholinesterase (AchE) inhibitor, is a novel compound that affects the brain cholinergic system through its potent inhibitory activity on acetylcholinesterase (AChE) and that is being developed to treat Alzheimer s disease. The inhibitory action is reversible and noncompetitive. Donepezil hydrochloride alleviated the impairment of memory acquisition caused by the lesion of the medial septum in rats in the water maze test.

关 键 词：盐酸多奈哌齐 AchE抑制剂 药效学 药动学 早老型痴呆 

分 类 号：R969[医药卫生—药理学]