蕊木宁在大鼠体内分布与排泄的动态研究(英文)  

Dynamic Studies on the Distribution and Excretion of ~3H-Kopsinine 1 in Rats

作　　者：王立强 李良桥[1,2] 苗立成 巫朝伦[1,2] 

机构地区：[1]哈尔滨150080 [2]解放军211医院

出　　处：《中国现代应用药学》2002年第1期32-35,共4页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的 :研究云南蕊木中有效成分蕊木宁在大鼠体内的组织分布与排泄。方法 :将蕊木宁用放射性元素 3H标记 ,分别以静注和口服方式给予受试大鼠 ,收集血液、脏器、尿液、胆汁等 ,用液体闪烁记数仪测量其放射活性。结果 :血中的放射活性呈二相衰减 ,t1/ 2α为 12 min,t1/ 2β 2 8.1h。口服给药 1h后 ,肝脏中的放射物浓度为 2 77.5± 17.8ng/ g,肾脏为 182 .4± 12 .0 ng/ g;并且 ,48h内 ,大部分放射活性 (6 6 % )由尿液排泄 ,小部分 (14% )由胆汁排泄。结论 :肝脏可能是蕊木宁的主要靶器官 。OBJECTIVE: To study the tissue distribution and excretion of 3H Kopsinine 1 in rats. METHODS: H Kopsinine 1 were administrated to 7 groups of 6 rats orally or intravenously, then blood, organ, urine,feces and bile were collected to prepare sample solutions. After 12 hours, the radioactivity was measured by Liquid Scintillation Counter. RESUTS: The radioactivity time curve can be described by a two compartment model. The T1/2α and the T1/2β is 12 minutes and 28.1 hours respectively. After oral administration the radioactivity in liver at 1 hour was 277.5±17.8ng/g and that in Kidney was 182.4±12.0ng/g. The majority (66%) of radioactivity was recovered from urine in 24 hours and 14% of radioactivity was from bile in 48 hours. CONCLUSION: Results suggest that liver is the main effective organ of Kopsinine 1, and also, Kopsinine 1 has a little possibility for enterohepatic circulation.

关 键 词：蕊木宁 分布 排泄 药代动力学 

分 类 号：R285[医药卫生—中药学] R282.71[医药卫生—中医学]