炙甘草汤及有效成分对组胺诱发离体豚鼠乳头肌触发活动及动作电位影响  

Influence of Zhigancao Decoction and Active Components on Triggered Activity and Action Potential by Histamine in Guinea Pig Papillary Muscle

作　　者：陈兰英[1] 陈奇[1] 刘荣华[1] 毕明[1] 

机构地区：[1]江西中医学院,南昌330006

出　　处：《中国实验方剂学杂志》2002年第1期41-43,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金课题 ( 3986 0 0 84)

摘　　要：炙甘草汤是古典名方 ,现临床用于治疗心律失常。本文用标准微电极技术观察离体豚鼠乳头肌动作电位的变化 ,研究炙甘草汤及有效成分抗组胺触发活动作用。炙甘草汤 (4 0mg ml)及有效成分 (1 36mg ml)能防治组胺 (2 0 0 μmol L)对APD50 和APD90 的缩短 ,并能防治组胺诱发的EAD ,DAD和TA的发生。Zhigancao Decoction is a famous traditional medicinal formula. At present the decoction can treat the arrhy thmia in clincical practice. By using standard microelectrode techniques to guinea pig papillary muscle, Zhigancao Decoction (40mg·ml -1 ) and active component (1 36 mg·ml -1 )could prolonge the shortening of APD 50 and APD 90 and reduced the incidence of triggered activities (EAD,DAD and TA) by histamine (200μmol·L -1 ).

关 键 词：灸甘草汤 有效成分 组胺 动作电位 触发活动 中药 药理 

分 类 号：R285.5[医药卫生—中药学]