多指标检测对诊断癌性胸腔积液的价值探讨  

ROLE OF COMBINED DETERMINATION OF CEA,CA50 AND EGF IN DIAGNOSIS OF MALIGNANT PLEURAL EFFUSION

作　　者：邵润霞[1] 张铁栓[1] 刘荣西[1] 

机构地区：[1]河南医科大学二附院呼吸内科,郑州450003

出　　处：《中国现代医学杂志》2002年第3期52-53,共2页China Journal of Modern Medicine

摘　　要：目的探讨诊断癌性胸腔积液快速、准确的方法。方法 :用免疫放射分析法联合检测 4 5例癌性胸液中癌胚抗原 (CEA)、糖链抗原 5 0 (CA5 0 )及表皮细胞生长因子 (EGF)水平 ,并以 4 0例结核性胸腔积液作对照。结果显示癌性胸液中CEA、CA5 0及EGF水平明显高于对照组 (P <0 .0 1) ;CA5 0和EGF单指标诊断癌性胸腔积液的敏感性和特异性均高于CEA(P <0 .0 5 )。三项指标联测诊断癌性胸腔积液的敏感性为 84 .4 % ,特异性为 94 .4 % ,准确性为 92 .3%。结论 :CEA、CA5 0及EGF的同步检测对诊断癌性胸腔积液有重要价值。Objective:To develop a rapid and precise way to diagnose malignant pleural effusion.Methods:Carcinoembryonic antigen (CEA),Carbohydrate antigen (CA50) and epidermal growth factor (EGF) in pleural effusion of 45 specimens of malignant pleural effusion and 40 samples of tuberculous pleural effusion were tested by the method of immunoradiometric assay (IRMA).Results:The levels of CEA,CA50 and EGF of malignant pleural effusion were significantly higher than those of the controls ( P <0.01);The sensitivity and specificity of CA50 and EGF in diagnosis of malignant pleural effusion were higher than those of CEA.When simultaneous analysis of CEA,CA50 and EGF in pleural effusion is performed,its sensitivity,specificity and accuracy in diagnosis of malignant pleural effusion were 94%,88.4% and 92.3% respectively.Conclusions:The combined determination of CEA,CA50 and EGF in pleural effusion is very important in diagnosis of malignant pleural effusion.

关 键 词：癌性胸腔积液 诊断 癌胚抗原 糖链抗原50 表皮细胞生长因子 

分 类 号：R561.304[医药卫生—呼吸系统]