谷氨酰胺颗粒对严重烧伤患者蛋白代谢和免疫功能的影响  

Effects of L-glutamine Granules on Protein Metabolism and Immunofunction in Severely Burned Patients

作　　者：彭曦[1] 尤忠义[1] 王风君[1] 王裴[1] 赵云[1] 汪仕良[1] 

机构地区：[1]第三军医大学西南医院烧伤研究所,重庆市400038

出　　处：《中国药房》2002年第1期36-37,共2页China Pharmacy

基　　金：军队科技进步一等奖 (96-1-8-1)项目;国家科技进步二等奖 (15-2-008-01)科研项目的部分内容

摘　　要：目的 :观察严重烧伤患者蛋白代谢和免疫功能的变化及口服谷氨酰胺颗粒剂的影响。方法 :采用随机双盲对照法 ,将烧伤总面积在30 %～60 %、Ⅲ°烧伤面积在20 %～50 %的39例患者随机分为谷氨酰胺治疗组 (20例 )和安慰剂对照组 (19例 )。治疗组每日服用谷氨酰胺颗粒剂0 5g/kg,对照组服用同等剂量的安慰剂 ,疗程为7天。检测用药前、后两组患者血中谷氨酰胺浓度、血浆前白蛋白、转铁蛋白和免疫球蛋白含量及血浆白细胞介素2(IL -2)水平 ,并记录患者的一般情况及30天创面愈合率和住院日。结果 :治疗组患者用药7天后 ,血浆谷氨酰胺、血浆前白蛋白、转铁蛋白及免疫球蛋白IgG、IgM和IL-2含量均显著高于用药前和对照组(P<0 01) ,而血浆IgA与用药前及与对照组相比 ,无显著性差异 (P>0 05)。与之对应 ,治疗组创面愈合加快 ,住院时间明显缩短。结论 :服用谷氨酰胺能显著提高严重烧伤患者血中谷氨酰胺水平 ,促进机体蛋白合成 ,减少蛋白分解 ,提高机体免疫功能 ,促进创面愈合率 ,缩短住院日。OBJECTIVE:To study the effect of L-glutamine granules on protein metabolism and immunofunction in severely burned patients.METHODS:39 severe burn patients(total burn surface areas 30%～60%,full thickness burn areas 20%～50%) were randomly divided into two groups:control group(C group,19 patients) and glutamine treatment group(GLN group,20 patients).GLN group patients were given glutamine granules 0.5g/kg daily for 7 days,and C group were given same weight placebo for 7 days.The concentrations of plasma glutamine,prealbumin,transferrin,immunological globulin and IL-2 were determined.Moreover,the wound healing rate of burn area was observed and then hospital stay days were recorded.RESULTS:After 7 days of taking glutamine,the concentrations of plasma glutamine,prealbumin,transferrin IgG,IgM and IL-2 in GLN group were significant higher than those in before medication and C group(P<0.01),but the concentration of IgA had no marked changes in comparison with C group(P>0.05).The wound healing rate was faster and hospital stay days were shorter in GLN group than those in C group(P<0.05).CONCLUSION:Taking glutamine could promote protein synthesis,enhance immunofunction,raise wound healing rate and reduce hospital stay day obviously.

关 键 词：谷氨酰胺 蛋白代谢 免疫功能 烧伤 治疗 临床应用 

分 类 号：R644[医药卫生—外科学]