双羟萘酸噻嘧啶咀嚼片抗猪蛔虫的药理效应  

The pharmacodynamics of pyrantel pamoate chewing tablet to pig ascarid

作　　者：熊玉卿[1] 周宪民[1] 傅军[1] 况荣华[2] 刘立生[2] 严涛[3] 彭卫东[4] 

机构地区：[1]江西医学院临床药理研究所,南昌330006 [2]江西医学院新药研究室,南昌330006 [3]江西医学院临床寄生虫教研室,南昌330006 [4]江西医学院寄生虫教研室,南昌330006

出　　处：《中国现代应用药学》2002年第1期21-24,共4页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的 :研究双羟萘酸噻嘧啶咀嚼片抗猪蛔虫的药理效应。方法 :将双羟萘酸噻嘧啶咀嚼片、普通片与阿苯哒唑等抗寄生虫药对小猪人工感染蛔虫病理模型进行治疗 ,采用改良加藤氏厚涂片法比较上述各药治疗前后的 EPG(克粪便虫卵数 )和虫卵阴转率。结果 :双羟萘酸噻嘧啶咀嚼片与片剂一样在肠虫营养液中 ,显著引起蛔虫虫体僵硬 ,导致猪蛔虫头颈段活动停止。双羟萘酸噻嘧啶咀嚼片 8m g· kg- 1 和 10 mg· kg- 1 组对小猪感染蛔虫均具有非常显著的驱治效果 ,治疗后虫卵阴转率达 97.2 6 %和 10 0 % (88h)、97.5 1%和 10 0 % (186 h) ,与阴性对照组比较有显著性差异 ;10 m g· kg- 1 组虫卵阴转率及 EPG显著高于阿苯哒唑 (肠虫清 )对照组 ,P<0 .0 5。急性毒性试验结果表明小鼠腹腔注射试验药混悬液 L D50 为 12 7.74～ 16 7.86 m g· kg- 1 ;小鼠累积灌胃给予该药的最小致死量大于 8g· kg- 1。结论OBJECTIVE: To study the pharmacodynamics of pyrantel pamoate chewing tablet in treatment of piglet infected ascarid artificially. METHODS: The Kato Kats method was used to report the piglet's EPG and ratio of ovum reduction. RESULTS: the drug can stiffen the ascarid body hatched in nutrition liquid. The ratio of ovum reduction is 97.26% and 100% (88h), 97.51% and 100%(186h). The ratio of ovum reduction for 88h and EPG is higher than Albendazole group ( P < 0.05 ). Acute toxicity study shows LD 50 of the prepration is 127.74～167.86 mg·kg -1 (i.p, 95% reliability) in mice; the minimum death dose in mice is more than 8g·kg -1 (i.g, 4 times per day accumulated). CONCLUSIONS: Pyrantel pamoate chewing tablet have a significant therapy effect on infected piglet.

关 键 词：双羟萘酸噻嘧啶 咀嚼片 药效学 猪蛔虫 药理效应 

分 类 号：R978.63[医药卫生—药品]