塞曲司特(Seratrodast)的合成  

Synthesis of seratrodast

作　　者：黄家卫 

机构地区：[1]浙江中医学院,杭州310053

出　　处：《中国现代应用药学》2002年第1期46-47,共2页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的 :合成塞曲司特并对其合成工艺进行改进。方法 :以庚二酸单乙酯为起始原料 ,经氯化、付 -克反应、还原、水解、缩合等步骤合成了塞曲司特。结果 :五步反应的总收率为 6 4% ,所得产物经熔点、红外光谱和核磁共振确证。结论 :此合成工艺可行 。OBJECTIVE: To Synthesize seratrodast and improve the synthetic process. METHODS: Seradtrodast was synthesized by steps of Chlorization Friedel Crafts reaction, reduction, hydrolysis and condensation from monoethyl pimelate. RESULTS: The total yield was 64%. Chemical structure of the product was confirmed by melting poind. IR and 1HNMR. CONCLUSION: This method was feasible and suitable for industry.

关 键 词：塞曲司特 合成 血栓素A2 受体拮抗制 平喘药 

分 类 号：TQ463[化学工程—制药化工] R974.3[医药卫生—药品]