疥疮霜的制备与质量控制  

The preparation and quality control of jiechuang cream

作　　者：张守尧[1] 古维新[1] 沈霞[1] 王桂芳[1] 

机构地区：[1]第一军医大学珠江医院,广州510282

出　　处：《中国现代应用药学》2002年第1期70-71,共2页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的 :研制治疗疥疮的新制剂并建立质量控制方法。方法 :在硫乳膏的基础上加入地塞米松等制成。质量控制采用HPL C法测定地塞米松的含量 ,容量法测定硫的含量。结果 :新制剂疥疮霜对疥疮的治愈率达 84.7% ;HPL C法测定地塞米松时的回收率为 10 0 .6 % ,RSD=0 .43%。结论 :疥疮霜疗效优于硫乳膏。OBJECTIVE: To prepare a new preparation for the therapy of scabies and to establish its quality control method. METHOD: The new preparation(jiechuang cream) was made by adding dexamethasone acetate to sulfur cream. The dexamethasone acetate was determined by HPLC method. The sulfur was determined by volumetric method. RESULTS: The cure rate for scabies of jiechuang cream was 84.7%. The average recovery and RSD of dexamethasone acetate were 100.6%, 0.43%. CONCLUTION: The jiechuang cream was better than sulfur cream on the treatment scabies. The quantitative analysis method can be used for the quality control of jiechuang cream.

关 键 词：疥疮霜 醋酸地塞米松 高效液相色谱法 质量控制 制备 

分 类 号：R986[医药卫生—药品]