类叶升麻苷对东莨菪碱所致记忆获得性障碍的改善作用  

Effects of acetoside on improving the ability of learning and memory in mice

作　　者：朴景华[1] 蒲小平[1] 马建[1] 李长龄[1] 宋志宏北京大学药学院天然药物学系 屠鹏飞[2] 

机构地区：[1]北京大学药学院分子与细胞药理学系,北京100083 [2]北京大学药学院天然药物学系,北京100083

出　　处：《中国药理学通报》2001年第6期625-627,共3页Chinese Pharmacological Bulletin

基　　金：国家重点基础研究发展规划项目课题 ;NoG19980 5 112 4

摘　　要：目的　观察类叶升麻苷对小鼠学习记忆能力的影响。方法　用东莨菪碱致小鼠记忆获得性障碍模型 ,以行为学实验 (跳台法、水迷路法 )、大脑皮层和纹状体乙酰胆碱酯酶活性和M受体的最大结合力为指标观察类叶升麻苷的作用。结果　在东莨菪碱致小鼠记忆障碍模型中 ,类叶升麻苷可延长跳台实验的平台停留期 ,并显著减少错误次数 ;在水迷路实验中可提高正确反应百分率 ;并能拮抗东莨菪碱所引起的大脑皮层乙酰胆碱酯酶的增高及皮层、纹状体M受体最大结合力的降低。结论　类叶升麻苷对东莨菪碱所引起的小鼠学习记忆能力障碍有改善作用 。AIM To investigate the effect of acetoside on the ability of learning and memory in mice. METHODS The dysmnesia model of acquired learning induced by scopolamine was used. The ability of learning and memory was measured by step through task and water maze task. The activity of acetylcholinesterase and M cholinergic receptors were determined. RESULTS Acetoside increased the retention latencies and decreased the number of avoidance response errors in step through task( P <0 05). In the water maze task, acetoside increased the correct percentage( P <0 05). Acetoside antagonized the increase of acetylcholinesterase and the decrease of Bmax of M cholinergic binding sites induced by scopolamine ( P <0 05). CONCLUSION Acetoside improves the disability of learning and memory induced by scopolamine, and its effect may be involved in the activity of the acetycholine system.

关 键 词：类叶升麻苷 学习记忆 乙酰胆碱酯酶 M受体 东莨菪碱 记忆获得性障碍 中药 动物实验 

分 类 号：R285.5[医药卫生—中药学]