赤芍总苷对D-半乳糖衰老小鼠学习记忆及代谢产物的影响  

Effects of total paeony glycoside on learning and memory capacity and related substances of senile Mice induced by D-galactose

作　　者：杨军[1] 王静[1] 姜文[2] 马传庚[3] 徐叔云[4] 

机构地区：[1]安徽省医学科学研究所省生物医药重点实验室,合肥230061 [2]安徽中医学院中药系 [3]安徽医科大学药理学教研室,合肥230032 [4]安徽医科大学临床药理研究所,合肥230032

出　　处：《中国药理学通报》2001年第6期697-699,共3页Chinese Pharmacological Bulletin

摘　　要：目的　观察赤芍总苷对D 半乳糖所致衰老小鼠学习记忆及与神经介质调节相关酶及代谢产物的影响。方法　选用长期皮下注射D 半乳糖形成的衰老小鼠模型。结果　赤芍总苷对衰老小鼠的学习记忆障碍有显著的改善作用 ,穿梭试验中小鼠主动回避潜伏期和主动回避次数明显增加 ;水迷宫试验发现 ,赤芍总苷可有效提高小鼠的达岸正确率 ,减少小鼠的错误次数。赤芍总苷可显著降低衰老小鼠脑组织中单胺氧化酶 (MAO)水平 ,提高胆碱酯酶 (CHE)活性 ;并抑制脂质过氧化产物丙二醛 (MDA)含量的增加 ,提高脑组织超氧化物岐化酶 (SOD)水平。此外 ,赤芍总苷对衰老小鼠免疫功能低下及脑萎缩状态有显著的改善。AIM To investigate actions of total paeony glycoside(TPG) on learning and memory capacity and related products of metabolism of senile mice induced by D galactose. METHODS The subacute senile mouse models induced by injection of D galactose subcutaneously were used. RESULTS TPG could improve the learning and memory capacity of model mice in shuttle test and enhance spatial resolution in water maze test. TPG not only reduced the content of monoamine oxidase(MAO) and inhibited the decrease of cholinesterase(CHE) significantly, but also lessened the level of malondialdehyde(MDA) and inhibited the decrease of superoxide dismutase(SOD) in cerebrum of model mice. TPG still promoted the recovery of lobar atrophy and hypoimmunity of senile mice remarkedly. CONCLUSION TPG possesses obvious effects of improvement on learning, spatial resolution and delaying senility.

关 键 词：赤芍总苷 D-半乳糖 记忆障碍 胆碱酯酶 学习记忆 中药 动物实验 

分 类 号：R282.71[医药卫生—中药学] R285.5[医药卫生—中医学]