二硫化碳对眼底视网膜血管的损害  

Effect of CS_2 on vascular damage in retina fundus oculi

作　　者：傅慰祖[1] 王文静[1] 陈俭华 吉志清 张阿根 项翠琴[1] 张胜年[1] 

机构地区：[1]上海市疾病预防控制中心,200336 [2]上海市眼病防治中心 [3]上海高桥石油化工有限公司职业病防治所

出　　处：《中华劳动卫生职业病杂志》2001年第6期442-443,共2页Chinese Journal of Industrial Hygiene and Occupational Diseases

摘　　要：目的　探讨低浓度长期接触二硫化碳 (CS2 )眼底视网膜血管损害的演变过程。方法　车间作业环境定点、定时检测CS2 浓度 ;对接触和对照 (各 10名 )工人进行眼底荧光血管造影。结果　CS2 平均接触水平在 10mg/m3 ,其中超过CS2 最高容许浓度 (10mg/m3 )的样品数平均为 17.8% (最高达 32 .6 % ) ,在此环境中接触 10年以上 ,眼底视网膜血管有异常者占 4 0 % ,对照无 1例异常 ,两者差异有显著性 (P <0 .0 5 )。结论　长期接触低浓度CS2 所致眼底视网膜血管损害由血管迂曲变细、充盈延迟→血管渗漏→微血管瘤形成演变过程 ,且有剂量 (接毒工龄 ) -效应关系。Objective To investigate the relationship between lasting low concentration of occupational exposure to CS 2 and vascular damage in retina fundus oculi. Methods The concentrations of CS 2 were determined in fixed workplaces on schedule time.Fundus oculi fluorescein angiography was conducted in the exposure and control groups. Results The samples beyond MAC(10 mg/m 3) were 17.8%(maximum 32.6%) on average.40% of the subjects exposed to CS 2 more than 10 years in the condition showed fundus oculi retinopathy in exposure group,while none did in control group( P <0.05). Conclusion The damage of retinal vascular induced by low concentration exposure to CS 2 for a long time showed the process of vascular circuity,attenuating,filling delay,vascular leakage,tiny haemangioma,and a dose effect relationship existed.

关 键 词：二硫化碳 眼底血管 损害 剂量-效应关系 二硫化碳中毒 职业中毒 

分 类 号：R135.9[医药卫生—劳动卫生]