粘胶工人尿2-硫代噻唑烷-4-羧酸浓度与神经传导速度的相关性研究  

Study on the relationship between 2-thiothiazolidine-4-carboxylic acid level in urine and nerve conduction velocity in rayon workers

作　　者：陶宁[1] 毕勇毅[1] 谭晓东[1] 李阳[1] 王福元[1] 

机构地区：[1]武汉大学公共卫生学院劳动卫生与环境卫生学教研室,430071

出　　处：《中华劳动卫生职业病杂志》2001年第6期447-449,共3页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：比利时ABOS基金资助 (13v13 496)

摘　　要：目的　探讨尿中 2 硫代噻唑烷 4 羧酸 (TTCA)含量作为内暴露指标在我国二硫化碳 (CS2 )接触工人神经系统功能职业健康监护方面的实际应用价值。方法　应用高效液相色谱法测定工人 8h班末尿TTCA含量 ,选取尿中TTCA <5mg/gCr者作为研究对象 ;应用常规方法测定工人腓总神经和腓肠神经传导速度及腓总神经F波最短潜伏期 ;用SAS软件包进行多元回归统计分析。结果　暴露组与对照组比较 ,工人神经传导速度的相关指标存在组间差异 :暴露组运动神经远端及近端动作电位波幅降低 (偏回归系数分别为 - 1.0 985、- 0 .95 5 7) ,F波最短潜伏期延长 (偏回归系数为 1.6 830 )。结论　就周围神经系统功能而言 ,尿TTCA含量可作为我国CS2 接触工人的一项敏感的内暴露指标。Objective To study the practical value of 2 thiothiazolidine 4 carboxylic acid(TTCA) in urine as an internal parameter in the occupational health surveillance of Chinese workers with exposure to carbon disulfide. Methods TTCA was determined in the urine of workers at the end of an 8 hour working shift by high performance liquid chromatography(HPLC),and the workers whose TTCA contents were below 5 mg/g creatinine were selected as study subjects.Nerve conduction velocity in common peroneal nerve and sural nerve and the minimum latency of F wave in common peroneal nerve were detected by routine methods.SAS software was used to confirm statistical difference by multiple linear regression. Results Comparison of exposed workers with controls by multiple linear regression revealed significant difference that the amplitude of the motor action potential decreased after distal and proximal stimulation( r =-1.098 5;-0.955 7) and the minimum latency of F wave prolonged in exposed battery( r =1.683 0). Conclusions The level of TTCA in urine is a valid internal exposure parameter for the peripheral nervous function in Chinese workers exposed to carbon disulfide.

关 键 词：二硫化碳 神经传导速度 2-硫代噻唑烷-4-羧酸 职业性疾病 预防 

分 类 号：R135.9[医药卫生—劳动卫生]