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机构地区:[1]第三军医大学附属西南医院普通外科,重庆400038
出 处:《第三军医大学学报》2001年第8期889-890,共2页Journal of Third Military Medical University
摘 要:目的 探讨血小板活化因子(PAF)及其拮抗剂在大鼠严重腹腔感染中的作用,及与肿瘤坏死因子(TNF)和IL-8的关系。方法 应用大鼠盲肠结扎加穿孔模型,在不同时相点观察大鼠死亡率并检测其血PAF、血清TNF及IL-8的水平。结果①严重腹腔感染后,血PAF、血清TNF及IL-8水平均明显升高,且前者与后两者呈显著正相关。②应用PAF拮抗剂WEB2170治疗后,血PAF、血清TNF及IL-8水平可显著降低。③WEB2170能明显降低严重腹腔感染大鼠的死亡率。结论 严重腹腔感染早期应用PAF拮抗剂可阻挡PAF与TNF和IL-8的网络联系,对防治多器官功能衰竭具有重要意义。Objective To investigate the role of platelet activating-factor (PAF) and its antagonist in serious intra-abdominal infection (SIAI) of rats, and the relationship between PAF and TNF or IL-8. Methods In a ligated and perforated cecum model of septic rat. The mortality and the level of blood PAF, serum TNF, IL-8 at different time points were observed. Results ①The level of blood PAF, serum TNF and IL-8 increased with a sig- nificant correlation between PAF and TNF/IL-8. ②After treated with PAF antagonist WEB2170, the level of blood PAF, serum TNF and IL-8 decreased with a reduced mortality rate. Conclusion The PAF antagonist WEB2170 can block the communication network of PAF with TNF or IL-8 and plays an important role in preventing MOF.
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