IgA肾病患者肾间质肥大细胞浸润的临床意义  

Clinical significance of mast cell infiltration in the interstitium of IgA nephritis

作　　者：左巍[1] 刘亚革[2] 张晓晨[3] 左伟[4] 赵红[1] 

机构地区：[1]沈阳军区总医院肾内科,辽宁沈阳110016 [2]沈阳军区总医院医学实验科,辽宁沈阳110016 [3]沈阳军区总医院检验科,辽宁沈阳110016 [4]沈阳军区总医院1肾内科2医学实验科3检验科,辽宁沈阳110016

出　　处：《细胞与分子免疫学杂志》2001年第6期545-546,共2页Chinese Journal of Cellular and Molecular Immunology

摘　　要：目的研究肥大细胞MC在IgA肾病患者肾间质中的分布及与间质纤维化的关系。方法采用甲苯胺蓝特殊染色法及MC特异酶(即类胰蛋白酶,tryptase免疫组化染色法对12例IgA肾病患者肾活检标本中的MC进行了观察。结果⑴肾脏皮、髓质均可见到MC多见于纤维化区域、血管周围、萎缩或扩张小管周围及肾小球周围。⑵系膜细胞的增殖程度与MC数无关而随着IgA肾病患者MC的数增加间质纤维化加重差异显著(P<0.025)。结论IgA肾病患者的肾间质中存在MC并与肾间质的纤维化有关。Aim To investigate the distribution of mast cells in the interstitium of the patients with IgA nephritis and the relationship between mast cells and interstitial fibrosis. Methods Tissue sections of renal biopsy from 12 patients with IgA nephritis were observed by special staining with toluidine blue and immunohistochemical staining with anti-human mast cell tryptase monoclonal antibodies. Results 1Mast cells positive for tryptase was seen in cortex or medullar,especially in interstitial fibrotic areas and around blood vessels, atrophic or dilatatic tubules and glomeruli. 2 The degree of mesangial proliferation did not correlate with the number of mast cells. However, with increase in the number of tryptase-positive mast cells, the interstitial fibrosis had become more severe (P<0.025). Conclusion Mast cells are one of the constitutive cells in the intersititium of IgA nephritis patients and may play a role in interstitial fibrosis.

关 键 词：IGA肾病 肥大细胞 类胰蛋白酶 肾间质 肾小球肾炎 

分 类 号：R692.31[医药卫生—泌尿科学]