纳络酮佐治新生儿呼吸衰竭随机对照试验  

A Randomly Controlled Study on Neonates with Respiratory Failure Treated Adjuvantly with Naloxone

作　　者：孙玲玲[1] 林英[1] 刘晓红[1] 

机构地区：[1]广东省深圳市儿童医院,518026

出　　处：《药物流行病学杂志》2001年第4期175-176,共2页Chinese Journal of Pharmacoepidemiology

摘　　要：目的 :观察盐酸纳洛酮佐治新生儿呼吸衰竭 (呼衰 )的疗效。方法 :将 6 2例呼衰的新生儿随机分为 2组 ,治疗组 30例 ,每次用纳洛酮 0 .1mg·kg-1,6～ 8h重复 1次 ,直至呼衰控制。对照组 32例 ,不予纳洛酮。结果 :治疗组在改善血气、控制临床症状、减少呼吸机使用时间、提高治疗有效率、减少神经系统及缺血性心肌损害并发症的发生等方面 ,与对照组差异明显。结论 :纳洛酮能够迅速地兴奋呼吸 ,改善通气和预后 。Objective: To observe the curative effect of neonates with respiratory failure treated adjuvomtly with naloxone. Methods: 62 cases, Who were ill with respiratory failure, were randomly divided into two group. 30 cases in treated group were given naloxone 0.1 mg·kg -1 , repeated every 6～8 hours until the respiratory failure was controlled. 32 cases in controlled group were not given naloxone. Results: There was a significant difference between both groups in improvement of blood gas, controlled clinical symtoms, decreased used time of respirator, raised therapeutical effective rate, decreased incidence of complications in nerve system and ischemic cardiac muscle damage. Conclusion: Naloxone can quickly stimulate respiration, improving breathing and prognosis, being a effective drug for treating adjuvantly children with respiratory failure.

关 键 词：纳络酮 呼吸衰竭 新生儿 随机对照试验 佐治 

分 类 号：R722.12[医药卫生—儿科]