荷移分光光度法测定尼可占替诺  

Spectrophotometric Determination of Xanthinol Nicotinate Based on Charge Transfer Reaction

作　　者：赵桂芝[1] 李华侃[1] 

机构地区：[1]锦州医学院,锦州121001

出　　处：《药物分析杂志》2002年第1期32-34,共3页Chinese Journal of Pharmaceutical Analysis

摘　　要：目的:通过尼可占替诺与氯冉酸的荷移反应来测定脑脉康制剂中尼可占替诺的含量。方法:用721型分光光度计,利用分光光度法进行测定。结果:反应在乙醇-丙酮(1:1)介质中进行,反应产物(荷移络合物)的最大吸收波长为530nm,表观摩尔吸收系数为1.18×10~3L·moL^(-1)·cm^(-1),RSD为0.9％(n=6),药物浓度在20～320mg·L^(-1)范围内呈线性关系。结论:此方法简便易行,条件易于控制,对实际样品的测定结果令人满意。Objective: To determine the content of xanthinol nicotinate through charge transfer reaction between xanthi- nol nicotinate and chloranilic acid. Method: By spectrophotometry method with 721 spectrophotometer. Results: The reaction between xanthinol nicotinate and chloranilic acid took place in ethanol - acetone. The apparent molar absorptivity is 1.18×10~3 L·mol-1·cm-1 at 530 nm. The relative standard deviation is 0.9% ( n = 6) . The Beer's law is obeyed in the range of 20-320 mg·L-1 of xanthinol nicotinate. Conclusions: The method is simple with easily - controlled reaction conditions and high sensitivity. The present method has been applied to the determination of xanthinol nicotinate in tablets with satisfactory results.

关 键 词：荷移反应 尼可占替诺 氯冉酸 荷移分光光度法 含量测定 脑脉康制剂 

分 类 号：R972.4[医药卫生—药品] R927.2[医药卫生—药学]