不稳定心绞痛心肌钙蛋白T测定的意义  

Clinical significance of assay the cardial troponin T in patients with unstable angina pectoris

作　　者：涂良珍[1] 邬丽娅[1] 吴进盛[1] 

机构地区：[1]新疆维吾尔自治区人民医院,新疆乌鲁木齐市830001

出　　处：《心血管康复医学杂志》2002年第1期21-22,共2页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的 :探讨心肌钙蛋白 T(c Tn T)对不稳定心绞痛 (U AP)危险分层的临床价值。方法 :用酶联免疫法测定80例 UAP患者入院当天、第 2天、第 3天血浆 c Tn T水平 ,据 c Tn T≥ 0 .1ng/ m l或 <0 .1ng/ ml将患者分为 c Tn T升高组和正常组 ,观察住院期间 UAP胸痛发作时 ST- T变化以及急性心肌梗死 (AMI)的发生率。结果 :在 80例 UAP中 c Tn T升高者 2 4例 (30 % ) ;正常者 5 6例 (70 % ) ;c Tn T升高者 2 4例中发生 AMI3例 (12 .5 % ) ,其中死亡 1例 ,c Tn T正常者无 1例发生 AMI或死亡 ;c Tn T升高组胸痛发作时的心电图 ST- T改变发生率 10 0 % (2 4/ 2 4)高于正常组的 0 % (0 / 5 6 ) (P<0 .0 1)。结论 :c Tn T测定对判断 U AP在短期内发生 AMI和心性死亡预测价值 ,可作为 UAP危险度分层指标。Objective:To explore the clinical value of risk of stratification in patients with unstable angina pectoris(UAP) by assay the cardiac troponin T (cTnT).Methods:The assay of cTnT was performed in 80 patients with UAP on the 1st?2nd?3rd day after hospitalization by enzyme linked immunoassay. According to cTnT levels(cTnT≥0.1 ng/ml or cTnT<0.1 ng/ml) the patients were divided into two groups: cTnT elevation group (24 cases)and cTnT normal group(56 cases).The changes of ST-T during episodes of chest pain and incidence of acute myocardial infarction (AMI) in hospital.Results: AMI occurred in 3 patients with class Ⅲ UAP in cTnT elevation group, in which 1 patient died. Death and AMI did not occurred in cTnT normal group. The incidence of ST-T changes (100%, 24/24) in cTnT elevation group was more than that (0%, 0/56)) in cTnT normal group( P <0.01).Conclusion:This study indicates that risk of stratification in patients with UAP by cTnT assay has very important significance.

关 键 词：心肌蛋白T 不稳定心绞痛 危险度分层 UAP 酶联免疫法 

分 类 号：R541.4[医药卫生—心血管疾病]