金丝桃甙与维生素E对小鼠脑肝组织的保护作用  

The Protective Effects of Hyperin and Vitamin E on the Tissues of Brain and Liver of Mice

作　　者：韩喻美[1] 赵小曼[1] 晏金平[2] 

机构地区：[1]江西医学院生物化学教研室,江西南昌330006 [2]江西省妇幼保健院检验科,江西南昌330006

出　　处：《江西医学院学报》2002年第1期37-38,共2页Acta Academiae Medicinae Jiangxi

摘　　要：目的 :本文探讨金丝桃甙与维生素E对小鼠脑肝组织的保护作用。方法 :采用小鼠脑肝组织进行体外培养 ,分别加入金丝桃甙、维生素E测其一氧化氮 (NO)、丙二醛 (MDA)、超氧化物歧化酶 (SOD)含量。结果 :金丝桃甙与维生素E均能增加组织SOD活性及NO含量 ,降低MDA水平 ,可能是其发挥药理作用的机制之一。结论Objective: To investigate the protective effects of hyperin and vitamin E on the tissues of brain and liver of mice. Methods: After the cells of brain and liver from mice were cultured in vitro with hyperin and vitamin E for a short time, their amounts of nitric oxide (NO), malondialdehyde (MDA), and superoxide dismutase (SOD) were determined. Results:Hyperin and vitamin E both increased SOD activity and NO amount of the tissues and decreased MDA level. Conclusion: Hyperin and vitamin E may play pharmacological roles in the protection of the tissues of brain and liver of mice.

关 键 词：金丝桃甙 药理学 脑肝组织 动物实验 维生素E 

分 类 号：R971[医药卫生—药品] R977.25[医药卫生—药学]