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作 者:曹伟建[1] 王家森[2] 杨春林[3] 钱义兵[1]
机构地区:[1]安徽省立医院安徽省立体定向神经外科研究所神经生化室,安徽合肥230001 [2]安徽省立医院心内科,安徽合肥230001 [3]安徽省立医院检验科,安徽合肥230001
出 处:《蚌埠医学院学报》2002年第2期123-125,共3页Journal of Bengbu Medical College
摘 要:目的 :探讨氧化修饰低密度脂蛋白 (oxLDL)、脂蛋白 (a) [Lp(a) ]、载脂蛋白A1 (ApoA1 )及载脂蛋白B1 0 0 (ApoB1 0 0 )在原发性高血压 (EH)发病、进展中的作用。方法 :应用双抗夹心ELISA法和免疫比浊法测定EH患者血液中oxLDL、Lp(a)、ApoA1 及ApoB1 0 0 含量。结果 :EH患者血液中oxLDL和ApoB1 0 0 明显高于正常对照组 (P <0 .0 5和P <0 .0 0 1 ) ,Lp(a)和ApoA1与正常对照组差异以及各项性别、年龄间差异均无显著性 (P >0 .0 5)。结论 :oxLDL、ApoB1 0 0 参与EH的病理过程 ,其升高是EH常伴有动脉粥样硬化的重要机制之一。Objective:To investigate the relation of lipoprotein and apolipoprotein with the pathogenesis of essential hypertension(EH).Methods:The levels of oxidatively modified low density lipoprotein(oxLDL),lipoprotein(a),apolipoprotein A\-1(ApoA\-1) and apolipoprotein B 100 (ApoB 100 ) in plasma or serum of patients with EH were determined by sandwich ELISA and immunoturbimetric method.Results:The levels of plasma oxLDL and serum ApoB 100 of EH group were obviously higher than those of normal control group( P < 0.05 and P <0.001).The differences of Lp(a) and ApoA\-1 in EH group from those in normal control group were not significant( P >0.05).There were no significant differences of sex and age between EH group and normal control group( P >0.05).Conclusions:OxLDL and ApoB 100 in the blood take part in pathologic course of EH and their decreases may be one of the important mechanisms of EH often accompanied by atherosclerosis(AS).
关 键 词:原发性高血压 动脉粥样硬化 脂蛋白类 LDL 载脂蛋白类 相关关系
分 类 号:R544.1[医药卫生—心血管疾病]
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